Abstract：
A thiophene-derived Schiff base ligand (E)-2-morpholino-N-(thiophen-2-ylmethylene)ethanamine was used for the synthesis of M(II) complexes, [TEM(M)X2] (M = Co, Cu, Zn; X = Cl; M = Cd, X = Br). Structural characterization of the synthesized complexes revealed distorted tetrahedral geometry around the M(II) center. In vitro investigation of the synthesized ligand and its M(II) complexes showed considerable anti-urease and leishmanicidal potential. The synthesized complexes also exhibited a significant inhibitory effect on urease, with IC50 values in the range of 3.50-8.05 μM. In addition, the docking results were consistent with the experimental results. A preliminary study of human colorectal cancer (HCT), hepatic cancer (HepG2), and breast cancer (MCF-7) cell lines showed marked anticancer activities of these complexes.
摘要：
噻吩衍生的席夫碱配体（E）-2-吗啉代-N-（噻吩-2-基亚甲基）乙胺用于合成M（II）配合物，[TEM(M)X2](M=Co,Cu,Zn;X=Cl;M=Cd,X=Br)。合成复合物的结构表征揭示了M（II）中心周围扭曲的四面体几何形状。对合成的配体及其M（II）配合物的体外研究显示出相当大的抗脲酶和杀利什曼潜力。合成的复合物对脲酶也有明显的抑制作用,IC50值在3.50-8.05μM的范围内。此外,对接结果与实验结果一致。人类结直肠癌（HCT）的初步研究，肝癌（HepG2），和乳腺癌（MCF-7）细胞系显示出这些复合物的显着抗癌活性。
