PDF(Pubmed)
Abstract：
Newly synthesized gemini quaternary ammonium salts (QAS) with different counterions (bromide, hydrogen chloride, methylcarbonate, acetate, lactate), chain lengths (C12, C14, C16) and methylene linker (3xCH2) were tested. Dihydrochlorides and dibromides with 12 carbon atoms in hydrophobic chains were characterized by the highest biological activity against planktonic forms of yeast and yeast-like fungi. The tested gemini surfactants also inhibited the production of filaments by C. albicans. Moreover, they reduced the adhesion of C. albicans cells to the surfaces of stainless steel, silicone and glass, and slightly to polystyrene. In particular, the gemini compounds with 16-carbon alkyl chains were most effective against biofilms. It was also found that the tested surfactants were not cytotoxic to yeast cells. Moreover, dimethylcarbonate (2xC12MeCO3G3) did not cause hemolysis of sheep erythrocytes. Dihydrochlorides, dilactate and diacetate showed no mutagenic potential.
摘要：
新合成的具有不同抗衡离子（溴化物，氯化氢,碳酸甲酯,醋酸盐,乳酸），测试链长(C12,C14,C16)和亚甲基接头(3xCH2)。疏水链中具有12个碳原子的二盐酸盐和二溴化物的特征是对浮游形式的酵母和酵母样真菌具有最高的生物活性。测试的双子表面活性剂还抑制白色念珠菌的长丝生产。此外，它们减少了白色念珠菌细胞对不锈钢表面的粘附，硅胶和玻璃，略带聚苯乙烯。特别是,具有16个碳烷基链的双子化合物对生物膜最有效。还发现所测试的表面活性剂对酵母细胞没有细胞毒性。此外，碳酸二甲酯(2xC12MeCO3G3)不引起绵羊红细胞溶血。二盐酸盐，二乳酸和二乙酸没有显示诱变潜力。
