PDF(Pubmed)
Abstract：
Diabetic foot ulcer (DFU) is a leading cause of high-level amputation in DM patients, with a low wound healing rate and a high incidence of infection. Vascular endothelial growth factor (VEGF) plays an important role in diabetes mellitus (DM) related complications. This study aims to explore the VEGF expression and its predictive value for prognosis in DFU, in order to provide basis for the prevention of DFU related adverse events. We analyzed 502 patients, with 328 in healing group and 174 in non-healing/recurrent group. The general clinical data and laboratory indicators of patients were compared through Spearman correlation analysis, ROC analysis and logistic regression analysis. Finally, the independent risk factors for adverse prognosis in DFU patients were confirmed. Spearman analysis reveals a positive correlation between the DFU healing rate and ABI, VEGF in wound tissue, and positive rate of VEGF expression, and a negative correlation with DM duration, FPG, HbA1c, TC, Scr, BUN, and serum VEGF. Further logistic regression analysis finds that the DM duration, FPG, HbA1c, ABI, serum VEGF, VEGF in wound tissue, and positive rate of VEGF expression are the independent risk factors for adverse prognosis in DFU (p < 0.05). DM duration, FPG, HbA1c, ABI, serum VEGF, VEGF in wound tissue, and positive rate of VEGF expression are the independent risk factors for prognosis in DFU patients. Patients with these risk factors should be screened in time, which is of great significance to prevent DFU related adverse events and improve outcomes.
摘要：
糖尿病足溃疡(DFU)是糖尿病患者高位截肢的主要原因,伤口愈合率低，感染发生率高。血管内皮生长因子(VEGF)在糖尿病(DM)相关并发症中起重要作用。本研究旨在探讨VEGF在DFU中的表达及其对预后的预测价值。为DFU相关不良事件的预防提供依据。我们分析了502名患者,愈合组328例，未愈合/复发组174例。通过Spearman相关分析比较患者的一般临床资料和实验室指标。ROC分析和logistic回归分析。最后,证实了DFU患者不良预后的独立危险因素.Spearman分析显示DFU愈合率与ABI呈正相关,伤口组织中的VEGF，VEGF表达阳性率,与DM持续时间呈负相关，FPG,HbA1c,TC,Scr,BUN,和血清VEGF。进一步的逻辑回归分析发现，DM持续时间，FPG,HbA1c,ABI,血清VEGF,伤口组织中的VEGF，VEGF表达阳性率是DFU不良预后的独立危险因素(p<0.05)。DM持续时间,FPG,HbA1c,ABI,血清VEGF,伤口组织中的VEGF，VEGF表达阳性率是影响DFU患者预后的独立危险因素。有这些危险因素的患者应及时筛查,这对预防DFU相关不良事件和改善预后具有重要意义。
