Abstract：
Nanoparticle-mediated thermotherapeutic research strives innovative, multifunctional, efficient, and safe treatments. Our study introduces a novel nanoplatform: the hollow magnetic vortex nanorings within a polydopamine layer (HMVNp), which exhibit dual functionality as magnetic and photothermal agents. Utilizing a \"Dual-mode\" approach, combining an alternating magnetic field (AMF) with near-infrared (NIR) laser irradiation, HMVNp demonstrated a significant enhancement in heating efficacy (58 ± 8 %, SAR = 1441 vs 1032 W/g) over traditional solid magnetite nanoparticles coated with polydopamine (SMNp). The unique geometry larger surface area to volume ratio facilitates efficient magnetic vortex dynamics and enhanced heat transfer. Addressing the challenge of heat resistant heat shock protein (Hsp) expression, encapsulated quercetin (Q) within HMVNp leverages tumor acidity and dual-mode thermal therapy to enhance release, showing a 28.8 ± 6.81 % increase in Q loading capacity compared to traditional SMNp. Moreover, HMVNp significantly improves contrast for both magnetic resonance imaging (MRI) and photoacoustic imaging (PAI), with an approximately 62 % transverse relaxation (R2 = 81.5 vs 31.6 mM-1s-1 [Fe]). In vivo studies showed that while single treatments slowed tumor growth, dual-mode therapy with quercetin significantly reduced tumors and effectively prevented metastases. Our study highlights the potential of HMVNp/Q as a versatile agent in thermotherapeutic interventions, offering improved diagnostic imaging capabilities.
摘要：
纳米粒子介导的热疗研究力求创新，多功能,高效,和安全的治疗。我们的研究引入了一种新颖的纳米平台：聚多巴胺层（HMVNp）内的中空磁性涡旋纳米环，它具有磁性和光热剂的双重功能。利用“双模”方法，将交变磁场（AMF）与近红外（NIR）激光照射相结合，HMVNp显示出加热效率的显着提高（58±8％，SAR=1441对1032W/g），而传统的固体磁铁矿纳米颗粒涂有聚多巴胺（SMNp）。独特的几何形状更大的表面积体积比有利于有效的磁涡旋动力学和增强的热传递。应对耐热热休克蛋白（Hsp）表达的挑战，HMVNp中包封的槲皮素（Q）利用肿瘤酸度和双模式热疗来增强释放，与传统SMNp相比，Q负载能力增加了28.8±6.81%。此外，HMVNp显著提高了磁共振成像（MRI）和光声成像（PAI）的对比度，具有约62%的横向弛豫(R2=81.5vs31.6mM-1s-1[Fe])。体内研究表明，虽然单一治疗减缓了肿瘤的生长，槲皮素双模式治疗可显着减少肿瘤并有效预防转移。我们的研究强调了HMVNp/Q作为热疗干预中通用药物的潜力，提供改进的诊断成像能力。
