Abstract：
The cerebellum is known to control the proper balance of isometric muscular contractions that maintain body posture. Current optogenetic manipulations of the cerebellar cortex output, however, have focused on ballistic body movements, examining movement initiation or perturbations. Here, by optogenetic stimulations of cerebellar Purkinje cells, which are the output of the cerebellar cortex, we evaluate body posture maintenance. By sequential analysis of body movement, we dissect the effect of optogenetic stimulation into a directly induced movement that is then followed by a compensatory reflex to regain body posture. We identify a module in the medial part of the anterior vermis which, through multiple muscle tone regulation, is involved in postural anti-gravity maintenance of the body. Moreover, we report an antero-posterior and medio-lateral functional segregation over the vermal lobules IV/V/VI. Taken together our results open new avenues for better understanding of the modular functional organization of the cerebellar cortex and its role in postural anti-gravity maintenance.
摘要：
已知小脑控制保持身体姿势的等距肌肉收缩的适当平衡。当前小脑皮质输出的光遗传学操作，然而,专注于弹道身体运动，检查运动开始或扰动。这里,通过光遗传学刺激小脑浦肯野细胞，小脑皮层的输出，我们评估身体姿势的维持。通过对身体运动的顺序分析，我们将光遗传学刺激的作用分解为直接诱导的运动，然后进行代偿反射以恢复身体姿势。我们确定了一个位于前椎骨内侧的模块，通过多种肌肉张力调节，参与身体的姿势反重力维持。此外，我们报告了在小叶IV/V/VI上的前后和中外侧功能分离。总之，我们的研究结果为更好地理解小脑皮层的模块化功能组织及其在姿势抗重力维持中的作用开辟了新的途径。
