Abstract：
The ongoing emergence of SARS-CoV-2 variants poses challenges to the immunity induced by infections and vaccination. We conduct a 6-month longitudinal evaluation of antibody binding and neutralization of sera from individuals with six different combinations of vaccination and infection against BA.5, XBB.1.5, EG.5.1, and BA.2.86. We find that most individuals produce spike-binding IgG or neutralizing antibodies against BA.5, XBB.1.5, EG.5.1, and BA.2.86 2 months after infection or vaccination. However, compared to ancestral strain and BA.5 variant, XBB.1.5, EG.5.1, and BA.2.86 exhibit comparable but significant immune evasion. The spike-binding IgG and neutralizing antibody titers decrease in individuals without additional antigen exposure, and <50% of individuals neutralize XBB.1.5, EG.5.1, and BA.2.86 during the 6-month follow-up. Approximately 57% of the 107 followed up individuals experienced an additional infection, leading to improved binding IgG and neutralizing antibody levels against these variants. These findings provide insights into the impact of SARS-CoV-2 variants on immunity following repeated exposure.
摘要：
SARS-CoV-2变体的持续出现对感染和疫苗接种诱导的免疫提出了挑战。我们对来自具有针对BA.5，XBB.1.5，EG.5.1和BA.2.86的六种不同疫苗接种和感染组合的个体的血清的抗体结合和中和进行了6个月的纵向评估。我们发现大多数个体在感染或接种疫苗2个月后产生针对BA.5、XBB.1.5、EG.5.1和BA.2.86的刺突结合IgG或中和抗体。然而,与祖先菌株和BA.5变体相比，XBB.1.5、EG.5.1和BA.2.86表现出相当但显著的免疫逃避。在没有额外抗原暴露的个体中，刺突结合IgG和中和抗体滴度降低，在6个月的随访期间,<50%的个体中和XBB.1.5、EG.5.1和BA.2.86。107名随访者中约有57％经历了额外的感染，导致针对这些变体的改善的结合IgG和中和抗体水平。这些发现提供了对SARS-CoV-2变体在重复暴露后对免疫的影响的见解。
