%0 Journal Article
%T Variant-specific antibody response following repeated SARS-CoV-2 vaccination and infection.
%A Jiang XL
%A Song XD
%A Shi C
%A Yang GJ
%A Wang XJ
%A Zhang YW
%A Wu J
%A Zhao LX
%A Zhang MZ
%A Wang MM
%A Chen RR
%A He XJ
%A Dai EH
%A Gao HX
%A Shen Y
%A Dong G
%A Wang YL
%A Ma MJ
%J Cell Rep
%V 43
%N 7
%D 2024 Jul 23
%M 38896777
暂无%R 10.1016/j.celrep.2024.114387
%X The ongoing emergence of SARS-CoV-2 variants poses challenges to the immunity induced by infections and vaccination. We conduct a 6-month longitudinal evaluation of antibody binding and neutralization of sera from individuals with six different combinations of vaccination and infection against BA.5, XBB.1.5, EG.5.1, and BA.2.86. We find that most individuals produce spike-binding IgG or neutralizing antibodies against BA.5, XBB.1.5, EG.5.1, and BA.2.86 2 months after infection or vaccination. However, compared to ancestral strain and BA.5 variant, XBB.1.5, EG.5.1, and BA.2.86 exhibit comparable but significant immune evasion. The spike-binding IgG and neutralizing antibody titers decrease in individuals without additional antigen exposure, and <50% of individuals neutralize XBB.1.5, EG.5.1, and BA.2.86 during the 6-month follow-up. Approximately 57% of the 107 followed up individuals experienced an additional infection, leading to improved binding IgG and neutralizing antibody levels against these variants. These findings provide insights into the impact of SARS-CoV-2 variants on immunity following repeated exposure.