Abstract：
Multifunctional hydrogel adhesives are highly desirable in wound healing applications, yet their preparation often requires complex material system design to achieve. Herein, a straightforward one-pot two-step polymerization method is developed to prepare adhesive hydrogels for wound dressing based on protocatechuic acid (PCA), polyacrylic acid (PAA), and polyamidoamine-epichlorohydrin (PAE), where PCA provides the catechol groups for strong adhesion, PAA serves as the primary polymer matrix, and PAE acts as a bridge connecting PCA and PAA. This design results in a PAA-PAE-PCA hydrogel having a remarkable instant 90-degree peeling interfacial toughness of 431 J m-2 on porcine skin, which is further amplified to 615 J m-2 after 30 minutes. The hydrogel also possesses the desired features for wound dressing, such as self-healing, antioxidant, anti-UV and antibacterial properties, good cytocompatibility, strong adhesion in use and weak adhesion on removal, as well as reversible and wet adhesion. Finally, in vivo data reveal that the PAA-PAE-PCA hydrogels can significantly accelerate wound healing, as evidenced by a noticeable reduction in the wound area and a diminished inflammatory response. Collectively, these results endorse the obtained multifunctional hydrogel as a promising candidate for wound healing and related fields.
摘要：
多功能水凝胶粘合剂在伤口愈合应用中是非常理想的，然而，他们的准备往往需要复杂的材料系统设计来实现。在这里，开发了一种简单的一锅两步聚合方法，以制备基于原儿茶酸（PCA）的伤口敷料用粘合剂水凝胶，聚丙烯酸(PAA),和聚酰胺胺-表氯醇（PAE），其中PCA提供邻苯二酚基团以强粘附力，PAA作为主要的聚合物基质，PAE充当连接PCA和PAA的桥梁。这种设计导致PAA-PAE-PCA水凝胶在猪皮肤上具有431Jm-2的显着即时90度剥离界面韧性，30分钟后进一步扩增至615Jm-2。水凝胶还具有伤口敷料所需的特征，比如自我修复，抗氧化剂，抗紫外线和抗菌性能，良好的细胞相容性,使用时附着力强，拆卸时附着力弱，以及可逆和湿粘附。最后,体内数据显示，PAA-PAE-PCA水凝胶可以显著加速伤口愈合，伤口面积明显减少，炎症反应减弱。总的来说，这些结果证明所获得的多功能水凝胶是伤口愈合和相关领域的有希望的候选物。
