{Reference Type}: Journal Article
{Title}: Multifunctional protocatechuic acid-polyacrylic acid hydrogel adhesives for wound dressings.
{Author}: Dong Y;Su J;Guo X;Zhang Q;Zhu S;Zhang K;Zhu H;
{Journal}: J Mater Chem B
{Volume}: 12
{Issue}: 27
{Year}: 2024 Jul 10
{Factor}: 7.571
{DOI}: 10.1039/d4tb00425f
{Abstract}: Multifunctional hydrogel adhesives are highly desirable in wound healing applications, yet their preparation often requires complex material system design to achieve. Herein, a straightforward one-pot two-step polymerization method is developed to prepare adhesive hydrogels for wound dressing based on protocatechuic acid (PCA), polyacrylic acid (PAA), and polyamidoamine-epichlorohydrin (PAE), where PCA provides the catechol groups for strong adhesion, PAA serves as the primary polymer matrix, and PAE acts as a bridge connecting PCA and PAA. This design results in a PAA-PAE-PCA hydrogel having a remarkable instant 90-degree peeling interfacial toughness of 431 J m-2 on porcine skin, which is further amplified to 615 J m-2 after 30 minutes. The hydrogel also possesses the desired features for wound dressing, such as self-healing, antioxidant, anti-UV and antibacterial properties, good cytocompatibility, strong adhesion in use and weak adhesion on removal, as well as reversible and wet adhesion. Finally, in vivo data reveal that the PAA-PAE-PCA hydrogels can significantly accelerate wound healing, as evidenced by a noticeable reduction in the wound area and a diminished inflammatory response. Collectively, these results endorse the obtained multifunctional hydrogel as a promising candidate for wound healing and related fields.