PDF(Pubmed)
Abstract：
Arterial stiffness is linked to age-related cognitive dysfunction. Estimated pulse wave velocity (ePWV) is associated with cerebrovascular disease. We sought to determine whether ePWV was associated with cognition in a multiethnic population.
We included 1257 participants enrolled in a Northern Manhattan Study magnetic resonance imaging MRI-cognitive study (mean age 64 ± 8 years, 61% women, 67% Hispanic, 18% non-Hispanic Black, 15% non-Hispanic white) and analyzed cognitive performance at two time points, at enrollment and on an average 5.0 ± 0.6 years later. ePWV was calculated using baseline age and blood pressure. Cognition and cognitive change scores were regressed on ePWV in multivariable linear regression models.
In adjusted models, ePWV (mean 11 ± 2 m/s) was significantly associated with cognition (b = -0.100, 95% CI, -0.120, -0.080) and cognitive change over time (b = -0.063, 95% CI, -0.082, -0.045). Effect modification by race and sex was found.
In this multiethnic population, the associations of ePWV with cognitive performance underline the role of vascular stiffness in age-related cognitive decline.
ePWV is a modest but independent predictor of cognitive function and cognitive decline among older individuals. After adjustment, the ePWV measure was inversely associated with performance and decline in global cognition, processing speed, episodic memory, executive function, and semantic memory. After adjustment, modification of the association between ePWV and change in episodic memory and executive function by race and ethnicity was suggested by a significant interaction term. The association between ePWV and episodic memory decline was stronger in females.
We included 1257 participants enrolled in a Northern Manhattan Study magnetic resonance imaging MRI-cognitive study (mean age 64 ± 8 years, 61% women, 67% Hispanic, 18% non-Hispanic Black, 15% non-Hispanic white) and analyzed cognitive performance at two time points, at enrollment and on an average 5.0 ± 0.6 years later. ePWV was calculated using baseline age and blood pressure. Cognition and cognitive change scores were regressed on ePWV in multivariable linear regression models.
In adjusted models, ePWV (mean 11 ± 2 m/s) was significantly associated with cognition (b = -0.100, 95% CI, -0.120, -0.080) and cognitive change over time (b = -0.063, 95% CI, -0.082, -0.045). Effect modification by race and sex was found.
In this multiethnic population, the associations of ePWV with cognitive performance underline the role of vascular stiffness in age-related cognitive decline.
ePWV is a modest but independent predictor of cognitive function and cognitive decline among older individuals. After adjustment, the ePWV measure was inversely associated with performance and decline in global cognition, processing speed, episodic memory, executive function, and semantic memory. After adjustment, modification of the association between ePWV and change in episodic memory and executive function by race and ethnicity was suggested by a significant interaction term. The association between ePWV and episodic memory decline was stronger in females.
摘要：
背景：动脉僵硬度与年龄相关的认知功能障碍有关。估计的脉搏波速度（ePWV）与脑血管疾病有关。我们试图确定ePWV是否与多种族人群的认知相关。
方法：我们纳入了1257名参加北曼哈顿研究磁共振成像MRI认知研究的参与者（平均年龄64±8岁，61%的女性，67%的西班牙裔,18%的非西班牙裔黑人,15%非西班牙裔白人)，并分析了两个时间点的认知表现，在入学时和平均5.0±0.6年后。使用基线年龄和血压计算ePWV。在多变量线性回归模型中，认知和认知变化评分基于ePWV进行回归。
结果：在调整后的模型中，ePWV（平均11±2m/s）与认知（b=-0.100，95％CI，-0.120，-0.080）和认知随时间的变化（b=-0.063，95％CI，-0.082，-0.045）显着相关。发现了种族和性别的效果变化。
结论：在这个多民族人口中，ePWV与认知表现的相关性强调了血管僵硬在年龄相关性认知衰退中的作用.
结论：ePWV是老年人认知功能和认知功能下降的适度但独立的预测因子。调整后,ePWV测量与全球认知的表现和下降呈负相关，处理速度,情景记忆,执行功能，和语义记忆。调整后,一个重要的相互作用术语表明，ePWV与情景记忆和执行功能的变化之间的关联因种族和种族而异。在女性中，ePWV与情景记忆下降之间的关联更强。
方法：我们纳入了1257名参加北曼哈顿研究磁共振成像MRI认知研究的参与者（平均年龄64±8岁，61%的女性，67%的西班牙裔,18%的非西班牙裔黑人,15%非西班牙裔白人)，并分析了两个时间点的认知表现，在入学时和平均5.0±0.6年后。使用基线年龄和血压计算ePWV。在多变量线性回归模型中，认知和认知变化评分基于ePWV进行回归。
结果：在调整后的模型中，ePWV（平均11±2m/s）与认知（b=-0.100，95％CI，-0.120，-0.080）和认知随时间的变化（b=-0.063，95％CI，-0.082，-0.045）显着相关。发现了种族和性别的效果变化。
结论：在这个多民族人口中，ePWV与认知表现的相关性强调了血管僵硬在年龄相关性认知衰退中的作用.
结论：ePWV是老年人认知功能和认知功能下降的适度但独立的预测因子。调整后,ePWV测量与全球认知的表现和下降呈负相关，处理速度,情景记忆,执行功能，和语义记忆。调整后,一个重要的相互作用术语表明，ePWV与情景记忆和执行功能的变化之间的关联因种族和种族而异。在女性中，ePWV与情景记忆下降之间的关联更强。
