PDF(Pubmed)
Abstract：
Long-term blood pressure variability (BPV) and plasma neurofilament light (pNfL) have been identified as potential biomarkers for Alzheimer\'s disease (AD) and cerebral small vessel disease (CSVD). However, the relationship between BPV, pNfL, and their association with the comorbidity of AD and CSVD remains unknown.
Participants with normal cognition and mild cognitive impairment from the Alzheimer\'s Disease Neuroimaging Initiative study were included in the data analysis. Linear mixed-effects regression models and causal mediation analyses were conducted to investigate the relationship among BPV, pNfL, comorbidity-related brain structural changes (hippocampal atrophy and white matter hyperintensities [WMH]), and cognitive function.
BPV was associated with pNfL, volumes of hippocampus and WMH, and cognition. pNfL mediated the effects of BPV on brain structural changes and cognition.
Our findings suggest a potential role of BPV and pNfL in the mechanism of comorbidity between AD and CSVD, underscoring the importance of BPV intervention in the general population.
Individuals with both Alzheimer\'s disease (AD) and cerebral small vessel disease (CSVD) pathologies had elevated blood pressure variability (BPV) and plasma neurofilament light (pNfL). The association between different components of BPV and brain structural changes may vary. BPV was associated with pNfL levels independent of average blood pressure. pNfL mediated the effects of BPV on comorbidity-related brain structural changes and cognitive performance.
Participants with normal cognition and mild cognitive impairment from the Alzheimer\'s Disease Neuroimaging Initiative study were included in the data analysis. Linear mixed-effects regression models and causal mediation analyses were conducted to investigate the relationship among BPV, pNfL, comorbidity-related brain structural changes (hippocampal atrophy and white matter hyperintensities [WMH]), and cognitive function.
BPV was associated with pNfL, volumes of hippocampus and WMH, and cognition. pNfL mediated the effects of BPV on brain structural changes and cognition.
Our findings suggest a potential role of BPV and pNfL in the mechanism of comorbidity between AD and CSVD, underscoring the importance of BPV intervention in the general population.
Individuals with both Alzheimer\'s disease (AD) and cerebral small vessel disease (CSVD) pathologies had elevated blood pressure variability (BPV) and plasma neurofilament light (pNfL). The association between different components of BPV and brain structural changes may vary. BPV was associated with pNfL levels independent of average blood pressure. pNfL mediated the effects of BPV on comorbidity-related brain structural changes and cognitive performance.
摘要：
背景：长期血压变异性（BPV）和血浆神经丝光（pNfL）已被确定为阿尔茨海默病（AD）和脑小血管病（CSVD）的潜在生物标志物。然而,BPV之间的关系，pNfL,它们与AD和CSVD共病的关系仍然未知。
方法：将来自阿尔茨海默病神经影像学倡议研究的认知正常和轻度认知障碍的参与者纳入数据分析。进行了线性混合效应回归模型和因果中介分析，以研究BPV之间的关系。pNfL,合并症相关的脑结构变化（海马萎缩和白质高强度[WMH]），和认知功能。
结果：BPV与pNfL相关，海马体和WMH的体积，和认知。pNfL介导BPV对脑结构改变和认知的影响。
结论：我们的研究结果表明，BPV和pNfL在AD和CSVD共病机制中的潜在作用，强调BPV干预在一般人群中的重要性。
结论：同时患有阿尔茨海默病（AD）和脑小血管病（CSVD）病理的个体血压变异性（BPV）和血浆神经丝光（pNfL）升高。BPV的不同成分与大脑结构变化之间的关联可能会有所不同。BPV与pNfL水平相关，与平均血压无关。pNfL介导BPV对合并症相关脑结构变化和认知表现的影响。
方法：将来自阿尔茨海默病神经影像学倡议研究的认知正常和轻度认知障碍的参与者纳入数据分析。进行了线性混合效应回归模型和因果中介分析，以研究BPV之间的关系。pNfL,合并症相关的脑结构变化（海马萎缩和白质高强度[WMH]），和认知功能。
结果：BPV与pNfL相关，海马体和WMH的体积，和认知。pNfL介导BPV对脑结构改变和认知的影响。
结论：我们的研究结果表明，BPV和pNfL在AD和CSVD共病机制中的潜在作用，强调BPV干预在一般人群中的重要性。
结论：同时患有阿尔茨海默病（AD）和脑小血管病（CSVD）病理的个体血压变异性（BPV）和血浆神经丝光（pNfL）升高。BPV的不同成分与大脑结构变化之间的关联可能会有所不同。BPV与pNfL水平相关，与平均血压无关。pNfL介导BPV对合并症相关脑结构变化和认知表现的影响。
