PDF(Pubmed)
Abstract：
UNASSIGNED: To investigate the causal relationship between gut microbiota (GM) and chalazion through Mendelian randomization (MR) analysis.
UNASSIGNED: GM-related genome-wide association studies (GWAS) were obtained from the International Consortium MiBioGen. Genetic data for chalazion were sourced from the MRC Integrative Epidemiology Unit (IEU) Open GWAS database. Five MR methods, including inverse variance weighted (IVW), were employed to estimate causal relationships. Cochran\'s Q test was used to detect heterogeneity, the MR-Egger intercept test and MR-PRESSO regression were utilized to detect horizontal pleiotropy, and the leave-one-out method was employed to validate data stability.
UNASSIGNED: We identified 1,509 single nucleotide polymorphisms (SNPs) across 119 genera as instrumental variables (IVs) (p < 1 × 10-5). According to the inverse variance weighted (IVW) estimate, the Family XIII AD3011 group (OR = 1.0018, 95% CI 1.0002-1.0035, p = 0.030) and Catenibacterium (OR = 1.0013, 95% CI 1.0002-1.0025, p = 0.022) were potentially associated with increased risk of chalazion. Conversely, Veillonella (OR = 0.9986, 95% CI 0.9974-0.9999, p = 0.036) appeared to provide protection against chalazion. There was no evidence of heterogeneity or pleiotropy.
UNASSIGNED: This study uncovered the causal relationship between GM and chalazion, pinpointing Catenibacterium and Family XIII AD3011 group as potential risk contributors, while highlighting Veillonella as a protective factor. In-depth investigation into the potential mechanisms of specific bacteria in chalazion was essential for providing novel therapeutic and preventive strategies in the future.
UNASSIGNED: GM-related genome-wide association studies (GWAS) were obtained from the International Consortium MiBioGen. Genetic data for chalazion were sourced from the MRC Integrative Epidemiology Unit (IEU) Open GWAS database. Five MR methods, including inverse variance weighted (IVW), were employed to estimate causal relationships. Cochran\'s Q test was used to detect heterogeneity, the MR-Egger intercept test and MR-PRESSO regression were utilized to detect horizontal pleiotropy, and the leave-one-out method was employed to validate data stability.
UNASSIGNED: We identified 1,509 single nucleotide polymorphisms (SNPs) across 119 genera as instrumental variables (IVs) (p < 1 × 10-5). According to the inverse variance weighted (IVW) estimate, the Family XIII AD3011 group (OR = 1.0018, 95% CI 1.0002-1.0035, p = 0.030) and Catenibacterium (OR = 1.0013, 95% CI 1.0002-1.0025, p = 0.022) were potentially associated with increased risk of chalazion. Conversely, Veillonella (OR = 0.9986, 95% CI 0.9974-0.9999, p = 0.036) appeared to provide protection against chalazion. There was no evidence of heterogeneity or pleiotropy.
UNASSIGNED: This study uncovered the causal relationship between GM and chalazion, pinpointing Catenibacterium and Family XIII AD3011 group as potential risk contributors, while highlighting Veillonella as a protective factor. In-depth investigation into the potential mechanisms of specific bacteria in chalazion was essential for providing novel therapeutic and preventive strategies in the future.
摘要：
■通过孟德尔随机化（MR）分析研究肠道微生物群（GM）与库拉齐隆之间的因果关系。
■GM相关的全基因组关联研究（GWAS）来自国际MiBioGen联盟。库拉兹病的遗传数据来自MRC综合流行病学单位（IEU）OpenGWAS数据库。五种MR方法，包括逆方差加权(IVW)，被用来估计因果关系。Cochran的Q检验用于检测异质性，利用MR-Egger截距检验和MR-PRESSO回归检测水平多效性，并采用留一法验证数据的稳定性。
■我们将119个属的1,509个单核苷酸多态性（SNP）鉴定为工具变量（IV）（p<1×10-5）。根据逆方差加权(IVW)估计，FamilyXIIIAD3011组(OR=1.0018,95%CI1.0002-1.0035,p=0.030)和副杆菌属(OR=1.0013,95%CI1.0002-1.0025,p=0.022)可能与妊娠的风险增加相关.相反，Veillonella（OR=0.9986，95％CI0.9974-0.9999，p=0.036）似乎提供了针对斑疹的保护。没有证据表明异质性或多效性。
■本研究揭示了GM与斑节鱼之间的因果关系，将子杆菌和家族XIIIAD3011组确定为潜在的风险贡献者，同时强调Veillonella是一种保护因素。深入研究特定细菌的潜在机制对于将来提供新的治疗和预防策略至关重要。
■GM相关的全基因组关联研究（GWAS）来自国际MiBioGen联盟。库拉兹病的遗传数据来自MRC综合流行病学单位（IEU）OpenGWAS数据库。五种MR方法，包括逆方差加权(IVW)，被用来估计因果关系。Cochran的Q检验用于检测异质性，利用MR-Egger截距检验和MR-PRESSO回归检测水平多效性，并采用留一法验证数据的稳定性。
■我们将119个属的1,509个单核苷酸多态性（SNP）鉴定为工具变量（IV）（p<1×10-5）。根据逆方差加权(IVW)估计，FamilyXIIIAD3011组(OR=1.0018,95%CI1.0002-1.0035,p=0.030)和副杆菌属(OR=1.0013,95%CI1.0002-1.0025,p=0.022)可能与妊娠的风险增加相关.相反，Veillonella（OR=0.9986，95％CI0.9974-0.9999，p=0.036）似乎提供了针对斑疹的保护。没有证据表明异质性或多效性。
■本研究揭示了GM与斑节鱼之间的因果关系，将子杆菌和家族XIIIAD3011组确定为潜在的风险贡献者，同时强调Veillonella是一种保护因素。深入研究特定细菌的潜在机制对于将来提供新的治疗和预防策略至关重要。
