PDF(Pubmed)
Abstract：
UNASSIGNED: The developmental age, comprising childhood and adolescence, constitutes an extremely important phase of neurodevelopment during which various psychiatric disorders can emerge. Obsessive-Compulsive Disorder (OCD) and Eating Disorders (ED) often manifest during this critical developmental period sharing similarities but also differences in psychopathology, neurobiology, and etiopathogenesis. The aim of this study is to focus on clinical, genetic and neurobiological similarities and differences in OCD and ED.
UNASSIGNED: This study is based on a PubMed/MEDLINE and Cochrane Central Register for Controlled Trial (CENTRAL). The research adhered to the guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).
UNASSIGNED: The aforementioned search yielded an initial collection of 335 articles, published from 1968 to September 2023. Through the application of inclusion and exclusion criteria, a total of 324 articles were excluded, culminating in a final selection of 10 articles.
UNASSIGNED: Our findings showed both differences and similarities between OCD and ED. Obsessive-compulsive (OC) symptoms are more prevalent in ED characterized by a binge/purge profile than in those with a restrictive profile during developmental age. OC symptomatology appears to be a common dimension in both OCD and ED. When presents, OC symptomatology, exhibits transversal characteristic alterations in the anterior cingulate cortex and poorer cognitive flexibility. These correlations could be highlighted by genetic overlaps between disorders. A comprehensive definition, integrating psychopathological and neurobiological aspects could significantly aid treatment selection and thereby influence the prognosis of these patients.
UNASSIGNED: This study is based on a PubMed/MEDLINE and Cochrane Central Register for Controlled Trial (CENTRAL). The research adhered to the guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).
UNASSIGNED: The aforementioned search yielded an initial collection of 335 articles, published from 1968 to September 2023. Through the application of inclusion and exclusion criteria, a total of 324 articles were excluded, culminating in a final selection of 10 articles.
UNASSIGNED: Our findings showed both differences and similarities between OCD and ED. Obsessive-compulsive (OC) symptoms are more prevalent in ED characterized by a binge/purge profile than in those with a restrictive profile during developmental age. OC symptomatology appears to be a common dimension in both OCD and ED. When presents, OC symptomatology, exhibits transversal characteristic alterations in the anterior cingulate cortex and poorer cognitive flexibility. These correlations could be highlighted by genetic overlaps between disorders. A comprehensive definition, integrating psychopathological and neurobiological aspects could significantly aid treatment selection and thereby influence the prognosis of these patients.
摘要：
■发育年龄，包括童年和青春期，构成神经发育的一个极其重要的阶段，在此期间可能出现各种精神疾病。强迫症（OCD）和进食障碍（ED）通常在这个关键的发育期表现出来，在精神病理学上有相似之处，但也有差异。神经生物学,和病因。这项研究的目的是专注于临床，强迫症和ED的遗传和神经生物学相似性和差异性。
■本研究基于PubMed/MEDLINE和Cochrane对照试验中央登记册（CENTRAL）。该研究遵循了系统审查和荟萃分析（PRISMA）的首选报告项目中概述的指南。
■上述搜索产生了335篇文章的初始集合，1968年至2023年9月出版。通过适用纳入和排除标准，共有324篇文章被排除在外，最终选择了10篇文章。
■我们的发现显示了强迫症和ED之间的差异和相似之处。强迫症（OC）症状在以暴饮暴食/清除特征为特征的ED中比在发育年龄具有限制性特征的ED中更为普遍。OC症状学似乎是强迫症和ED的共同维度。当礼物,OC症状学，在前扣带回皮质中表现出横向特征性改变，认知灵活性较差。这些相关性可以通过疾病之间的遗传重叠来突出显示。一个全面的定义，整合精神病理学和神经生物学方面可以显着帮助治疗选择，从而影响这些患者的预后。
■本研究基于PubMed/MEDLINE和Cochrane对照试验中央登记册（CENTRAL）。该研究遵循了系统审查和荟萃分析（PRISMA）的首选报告项目中概述的指南。
■上述搜索产生了335篇文章的初始集合，1968年至2023年9月出版。通过适用纳入和排除标准，共有324篇文章被排除在外，最终选择了10篇文章。
■我们的发现显示了强迫症和ED之间的差异和相似之处。强迫症（OC）症状在以暴饮暴食/清除特征为特征的ED中比在发育年龄具有限制性特征的ED中更为普遍。OC症状学似乎是强迫症和ED的共同维度。当礼物,OC症状学，在前扣带回皮质中表现出横向特征性改变，认知灵活性较差。这些相关性可以通过疾病之间的遗传重叠来突出显示。一个全面的定义，整合精神病理学和神经生物学方面可以显着帮助治疗选择，从而影响这些患者的预后。
