Drug-Modified Contact Lenses-Properties, Release Kinetics, and Stability of Active Substances with Particular Emphasis on Cyclosporine A: A Review.

药物改性隐形眼镜 - 性能 ，释放动力学,特别是环孢素 A 的活性物质和稳定性 ： 综述。

• 影响指数: 4.927
• 发表时间: 2024 Jun 1
• 来源期刊: Molecules
• DOI: 10.3390/molecules29112609
• PMID: 38893485
• 文章类型: Journal Article
• 中科院分区: Q3
• 作者列表: Rykowska I,Michałkiewicz O,Nowak I,Nowak R

关键词: Cyclosporine A stability; drug delivery systems; drug stability; mechanic parameters; polymer matrix; therapeutic contact lenses

Mesh: Cyclosporine / chemistry; Humans; Drug Liberation; Kinetics; Drug Delivery Systems; Contact Lenses, Hydrophilic; Drug Stability; Polymers / chemistry

Abstract

The following review focuses on the manufacturing and parameterizing of ocular drug delivery systems (DDS) using polymeric materials to create soft contact lenses. It discusses the types of drugs embedded into contact lenses, the various polymeric materials used in their production, methods for assessing the mechanical properties of polymers, and techniques for studying drug release kinetics. The article also explores strategies for investigating the stability of active substances released from contact lenses. It specifically emphasizes the production of soft contact lenses modified with Cyclosporine A (CyA) for the topical treatment of specific ocular conditions. The review pays attention to methods for monitoring the stability of Cyclosporine A within the discussed DDS, as well as investigating the influence of polymer matrix type on the stability and release of CyA.

摘要

以下综述集中于使用聚合物材料制造软性隐形眼镜的眼部药物递送系统(DDS)的制造和参数化。它讨论了嵌入隐形眼镜的药物类型，生产中使用的各种聚合物材料，评估聚合物机械性能的方法，和研究药物释放动力学的技术。本文还探讨了研究隐形眼镜释放的活性物质稳定性的策略。它特别强调生产用环孢菌素A（CyA）修饰的软性隐形眼镜，用于局部治疗特定的眼部疾病。该综述关注在讨论的DDS中监测环孢菌素A稳定性的方法，以及研究聚合物基质类型对CyA的稳定性和释放的影响。