PDF(Pubmed)
Abstract：
Zeta potential refers to the electrokinetic potential present in colloidal systems, exerting significant influence on the diverse properties of nano-drug delivery systems. The impact of the dielectric constant on the zeta potential and charge inversion of highly charged colloidal particles immersed in a variety of solvents spanning from polar, such as water, to nonpolar solvents and in the presence of multivalent salts was investigated through primitive Monte Carlo (MC) model simulations. Zeta potential, ξ, is decreased with the decreasing dielectric constant of the solvent and upon further increase in the salinity and the valency of the salt. At elevated levels of salt, the colloidal particles become overcharged in all solvents. As a result, their apparent charge becomes opposite in sign to the stoichiometric charge. This reversal of charge intensifies until reaching a saturation point with further increase in salinity.
摘要：
Zeta电位是指胶体系统中存在的电动电位，对纳米药物递送系统的不同性质产生重大影响。介电常数对Zeta电位和电荷反转的影响浸入各种溶剂中的高电荷胶体颗粒，比如水,通过原始蒙特卡罗（MC）模型模拟研究了非极性溶剂和多价盐存在下。Zeta电位,ζ,随着溶剂介电常数的降低以及盐的盐度和化合价的进一步增加而降低。在盐含量升高的情况下，胶体颗粒在所有溶剂中变得过充电。因此,它们的表观电荷与化学计量电荷的符号相反。随着盐度的进一步增加，这种电荷的逆转会加剧，直到达到饱和点。
