PDF(Pubmed)
Abstract：
Objectives: A growing body of evidence highlights the effects of air pollution on chronic and acute cardiovascular diseases, such as associations between PM10 and several cardiovascular events. However, evidence of the impact of fine air pollutants on the development and progression of peripheral arterial aneurysms is not available. Methods: Data were obtained from the multicenter PAA outcome registry POPART and the German Environment Agency. Means of the mean daily concentration of PM10, PM2.5, NO2, and O3 concentrations were calculated for 2, 10, and 3650 days prior to surgery for each patient. Additionally, weighted ten-year averages were analyzed. Correlation was assessed by calculating Pearson correlation coefficients, and regression analyses were conducted as multiple linear or multiple logistic regression, depending on the dependent variable. Results: For 1193 patients from the POPART registry, paired air pollution data were available. Most patients were male (95.6%) and received open surgical repair (89.9%). On a regional level, the arithmetic means of the daily means of PM10 between 2000 and 2022 were neither associated with average diameters nor runoff vessels. Negative correlations for mean PAA diameter and mean NO2, as well as a positive correlation with mean O3, were found; however, they were not statistically significant. On patient level, no evidence for an association of mean PM10 exposure over ten years prior to inclusion in the registry and PAA diameter or the number of runoff vessels was found. Weighted PM10, NO2, and O3 exposure over ten years also did not result in significant associations with aneurysm diameter or runoff vessels. Short-term air pollutant concentrations were not associated with symptomatic PAAs or with perioperative complications. Conclusions: We found no indication that long-term air pollutant concentrations are associated with PAA size or severity, neither on a regional nor individual level. Additionally, short-term air pollution showed no association with clinical presentation or treatment outcomes.
摘要：
目标：越来越多的证据强调空气污染对慢性和急性心血管疾病的影响，例如PM10与一些心血管事件之间的关联。然而,目前尚没有证据证明空气中的细微污染物对周围动脉动脉瘤的发展和进展有影响.方法：数据来自多中心PAA结果注册表POPART和德国环境署。计算每位患者手术前2、10和3650天的PM10，PM2.5，NO2和O3平均日浓度平均值。此外,对加权十年平均值进行了分析。通过计算皮尔逊相关系数来评估相关性，回归分析为多元线性或多元逻辑回归，取决于因变量。结果：对于POPART注册的1193名患者，成对的空气污染数据可用。大多数患者为男性（95.6％），并接受了开放手术修复（89.9％）。在区域层面,2000年至2022年PM10日平均值的算术平均值与平均直径和径流船只无关。发现平均PAA直径和平均NO2呈负相关，与平均O3呈正相关；然而，它们没有统计学意义。在患者层面，没有证据表明在纳入登记前10年的平均PM10暴露量与PAA直径或径流血管数量之间存在关联.经过十年的加权PM10，NO2和O3暴露也没有导致与动脉瘤直径或径流血管的显着关联。短期空气污染物浓度与有症状的PAA或围手术期并发症无关。结论：我们没有发现长期空气污染物浓度与PAA大小或严重程度相关的迹象。无论是在区域还是个人层面。此外,短期空气污染与临床表现或治疗结局无关.
