PDF(Pubmed)
Abstract：
Dietary intake and alcohol consumption might be influenced by genetic variations in taste receptor genes. The objectives of this study were to examine the relationship between polymorphisms in the bitter taste receptor genes TAS2R13 (rs1015443) and TAS2R38 (rs1726866, rs10246939, and rs713598) as well as alcohol consumption and body fat percentage in college students. Four hundred and two students with a mean age of 20.2 years participated in this study. An NIH Diet History Questionnaire (DHQ II) was used to collect data on their dietary intake, while an AUDIT survey was used to determine their level of alcohol consumption. Bitter taste receptor gene polymorphisms were assessed by TaqMan allelic discrimination assays. Despite significant associations between TAS2R13 (rs1015443) and certain aspects of alcohol consumption, including the frequency of alcohol intake, no significant associations were found between TAS2R13 (rs1015443) and alcohol consumption after accounting for confounding variables in the regression model. Neither association was found regarding percent of body fat. In contrast, ethnicity and gender significantly influenced percent of body fat (p < 0.001), while no significant association was observed between TAS2R13 (rs1015443) and percent of body fat. Likewise, TAS2R38 (rs1726866, rs10246939, and rs713598) demonstrated no significant association with alcohol consumption and percent of body fat. These results were controlled for confounding factors, such as ethnicity and gender. Body fat percentage and alcohol consumption may be influenced by ethnicity, gender, and age rather than SNPs of TAS2R13 and TAS2R38 genes. Assessing taste genes\' interactions with diet and body composition might be useful in identifying human disease risk.
摘要：
饮食摄入和饮酒可能受到味觉受体基因遗传变异的影响。本研究的目的是检查大学生的苦味受体基因TAS2R13（rs1015443）和TAS2R38（rs1726866，rs10246939和rs713598）的多态性以及饮酒和体脂百分比之间的关系。400名平均年龄为20.2岁的学生参加了这项研究。NIH饮食史问卷（DHQII）用于收集有关其饮食摄入量的数据，而AUDIT调查被用来确定他们的酒精消费水平。通过TaqMan等位基因区分测定评估苦味受体基因多态性。尽管TAS2R13(rs1015443)与酒精消费的某些方面存在显著关联，包括酒精摄入的频率，在回归模型中考虑混杂变量后,未发现TAS2R13(rs1015443)与饮酒之间存在显著关联.关于体内脂肪的百分比都没有发现任何关联。相比之下,种族和性别显著影响身体脂肪百分比(p<0.001)，而TAS2R13（rs1015443）与体脂百分比之间没有显着关联。同样，TAS2R38（rs1726866，rs10246939和rs713598）与饮酒和体脂百分比没有显着关联。这些结果受到混杂因素的控制，比如种族和性别。身体脂肪百分比和饮酒可能受到种族的影响，性别,和年龄，而不是TAS2R13和TAS2R38基因的SNP。评估味觉基因与饮食和身体成分的相互作用可能有助于识别人类疾病风险。
