PDF(Pubmed)
Abstract：
This review aimed to examine the effects of curcumin on chronic inflammatory metabolic disease by extensively evaluating meta-analyses of randomized controlled trials (RCTs). We performed a literature search of meta-analyses of RCTs published in English in PubMed®/MEDLINE up to 31 July 2023. We identified 54 meta-analyses of curcumin RCTs for inflammation, antioxidant, glucose control, lipids, anthropometric parameters, blood pressure, endothelial function, depression, and cognitive function. A reduction in C-reactive protein (CRP) levels was observed in seven of ten meta-analyses of RCTs. In five of eight meta-analyses, curcumin intake significantly lowered interleukin 6 (IL-6) levels. In six of nine meta-analyses, curcumin intake significantly lowered tumor necrosis factor α (TNF-α) levels. In five of six meta-analyses, curcumin intake significantly lowered malondialdehyde (MDA) levels. In 14 of 15 meta-analyses, curcumin intake significantly reduced fasting blood glucose (FBG) levels. In 12 of 12 meta-analyses, curcumin intake significantly reduced homeostasis model assessment of insulin resistance (HOMA-IR). In seven of eight meta-analyses, curcumin intake significantly reduced glycated hemoglobin (HbA1c) levels. In eight of ten meta-analyses, curcumin intake significantly reduced insulin levels. In 14 of 19 meta-analyses, curcumin intake significantly reduced total cholesterol (TC) levels. Curcumin intake plays a protective effect on chronic inflammatory metabolic disease, possibly via improved levels of glucose homeostasis, MDA, TC, and inflammation (CRP, IL-6, TNF-α, and adiponectin). The safety and efficacy of curcumin as a natural product support the potential for the prevention and treatment of chronic inflammatory metabolic diseases.
摘要：
本综述旨在通过广泛评估随机对照试验（RCTs）的荟萃分析来研究姜黄素对慢性炎症性代谢性疾病的影响。我们对截至2023年7月31日以英文发表在PubMed®/MEDLINE上的RCT的荟萃分析进行了文献检索。我们确定了54项姜黄素RCTs用于炎症的荟萃分析，抗氧化剂，血糖控制,脂质，人体测量参数,血压,内皮功能，抑郁症,和认知功能。在10项随机对照试验的meta分析中有7项观察到C反应蛋白（CRP）水平降低。在八个荟萃分析中的五个，姜黄素摄入显着降低白细胞介素6（IL-6）水平。在九项荟萃分析中，姜黄素的摄入显着降低了肿瘤坏死因子α（TNF-α）的水平。在六项荟萃分析中，姜黄素摄入量显著降低丙二醛（MDA）水平。在15项荟萃分析中的14项，姜黄素摄入显著降低空腹血糖（FBG）水平。在12项荟萃分析中的12项，姜黄素摄入显着降低胰岛素抵抗（HOMA-IR）的稳态模型评估。在八项荟萃分析中，姜黄素摄入显着降低糖化血红蛋白（HbA1c）水平。在十个荟萃分析中的八个，姜黄素摄入显著降低胰岛素水平。在19项荟萃分析中的14项，姜黄素摄入显著降低总胆固醇（TC）水平。姜黄素对慢性炎症性代谢性疾病具有保护作用,可能通过改善葡萄糖稳态水平，MDA,TC,和炎症（CRP，IL-6,TNF-α,和脂联素）。姜黄素作为天然产物的安全性和有效性支持预防和治疗慢性炎性代谢疾病的潜力。
