PDF(Pubmed)
Abstract：
BACKGROUND: Short-chain fatty acids (SCFAs) have been reported to be associated with the pathogenesis of irritable bowel syndrome (IBS), but the results are conflicting.
OBJECTIVE: Here, a systematic review of case-control studies detecting fecal SCFAs in IBS patients compared with healthy controls (HCs) and self-controlled studies or randomized controlled trials (RCTs) investigating fecal SCFA alterations after interventions were identified from several databases.
METHODS: A systematic search of databases (PubMed, Web of Science, and Embase) identified 21 studies published before 24 February 2023. Data extractions: Three independent reviewers completed the relevant data extraction.
METHODS: It was found that the fecal propionate concentration in IBS patients was significantly higher than that in HCs, while the acetate proportion was significantly lower. Low-FODMAP diets significantly reduced the fecal propionate concentration in the IBS patients while fecal microbiota transplantation and probiotic administration did not significantly change the fecal propionate concentration or acetate proportion.
CONCLUSIONS: The results suggested that the fecal propionate concentration and acetate proportion could be used as biomarkers for IBS diagnosis. A low-FODMAP diet intervention could potentially serve as a treatment for IBS while FMT and probiotic administration need more robust trials.
OBJECTIVE: Here, a systematic review of case-control studies detecting fecal SCFAs in IBS patients compared with healthy controls (HCs) and self-controlled studies or randomized controlled trials (RCTs) investigating fecal SCFA alterations after interventions were identified from several databases.
METHODS: A systematic search of databases (PubMed, Web of Science, and Embase) identified 21 studies published before 24 February 2023. Data extractions: Three independent reviewers completed the relevant data extraction.
METHODS: It was found that the fecal propionate concentration in IBS patients was significantly higher than that in HCs, while the acetate proportion was significantly lower. Low-FODMAP diets significantly reduced the fecal propionate concentration in the IBS patients while fecal microbiota transplantation and probiotic administration did not significantly change the fecal propionate concentration or acetate proportion.
CONCLUSIONS: The results suggested that the fecal propionate concentration and acetate proportion could be used as biomarkers for IBS diagnosis. A low-FODMAP diet intervention could potentially serve as a treatment for IBS while FMT and probiotic administration need more robust trials.
摘要：
背景：据报道，短链脂肪酸（SCFA）与肠易激综合征（IBS）的发病机制有关，但是结果是相互矛盾的。
目标：这里，从多个数据库中确定了一项系统性综述,该系统综述了IBS患者粪便SCFA与健康对照(HCs)的比较,以及调查干预后粪便SCFA改变的自身对照研究或随机对照试验(RCT).
方法：对数据库的系统搜索(PubMed，WebofScience,和Embase）确定了2023年2月24日之前发表的21项研究。数据提取：三位独立审稿人完成了相关数据提取。
方法：发现IBS患者的粪便丙酸浓度明显高于HCs，而乙酸盐比例明显降低。低FODMAP饮食显着降低了IBS患者的粪便丙酸浓度，而粪便微生物群移植和益生菌给药并未显着改变粪便丙酸浓度或乙酸盐比例。
结论：结果表明，粪便丙酸浓度和乙酸盐比例可作为IBS诊断的生物标志物。低FODMAP饮食干预可能作为IBS的治疗方法，而FMT和益生菌管理需要更有力的试验。
目标：这里，从多个数据库中确定了一项系统性综述,该系统综述了IBS患者粪便SCFA与健康对照(HCs)的比较,以及调查干预后粪便SCFA改变的自身对照研究或随机对照试验(RCT).
方法：对数据库的系统搜索(PubMed，WebofScience,和Embase）确定了2023年2月24日之前发表的21项研究。数据提取：三位独立审稿人完成了相关数据提取。
方法：发现IBS患者的粪便丙酸浓度明显高于HCs，而乙酸盐比例明显降低。低FODMAP饮食显着降低了IBS患者的粪便丙酸浓度，而粪便微生物群移植和益生菌给药并未显着改变粪便丙酸浓度或乙酸盐比例。
结论：结果表明，粪便丙酸浓度和乙酸盐比例可作为IBS诊断的生物标志物。低FODMAP饮食干预可能作为IBS的治疗方法，而FMT和益生菌管理需要更有力的试验。
