PDF(Pubmed)
Abstract：
The onset of puberty, which is under the control of the hypothalamic-pituitary-gonadal (HPG) axis, is influenced by various factors, including obesity, which has been associated with the earlier onset of puberty. Obesity-induced hypothalamic inflammation may cause premature activation of gonadotropin-releasing hormone (GnRH) neurons, resulting in the development of precocious or early puberty. Mechanisms involving phoenixin action and hypothalamic microglial cells are implicated. Furthermore, obesity induces structural and cellular brain alterations, disrupting metabolic regulation. Imaging studies reveal neuroinflammatory changes in obese individuals, impacting pubertal timing. Magnetic resonance spectroscopy enables the assessment of the brain\'s neurochemical composition by measuring key metabolites, highlighting potential pathways involved in neurological changes associated with obesity. In this article, we present evidence indicating a potential association among obesity, hypothalamic inflammation, and precocious puberty.
摘要：
青春期的开始，在下丘脑-垂体-性腺（HPG）轴的控制下，受各种因素的影响，包括肥胖,这与青春期的早期发作有关。肥胖诱导的下丘脑炎症可能导致促性腺激素释放激素（GnRH）神经元过早激活，导致早熟或早熟的发展。涉及phoenixin作用和下丘脑小胶质细胞的机制。此外，肥胖会导致大脑结构和细胞改变，扰乱代谢调节。影像学研究揭示了肥胖个体的神经炎症变化，影响青春期的时间。磁共振波谱能够通过测量关键代谢物来评估大脑的神经化学成分，强调与肥胖相关的神经系统变化的潜在途径。在这篇文章中,我们提供的证据表明肥胖之间存在潜在的关联，下丘脑炎症,和性早熟.
