PDF(Pubmed)
Abstract：
This comprehensive review delineates the extensive roles of Akkermansia muciniphila in various health domains, spanning from metabolic and inflammatory diseases to neurodegenerative disorders. A. muciniphila, known for its ability to reside in the mucous layer of the intestine, plays a pivotal role in maintaining gut integrity and interacting with host metabolic processes. Its influence extends to modulating immune responses and potentially easing symptoms across several non-communicable diseases, including obesity, diabetes, inflammatory bowel disease, and cancer. Recent studies highlight its capacity to interact with the gut-brain axis, suggesting a possible impact on neuropsychiatric conditions. Despite the promising therapeutic potential of A. muciniphila highlighted in animal and preliminary human studies, challenges remain in its practical application due to stability and cultivation issues. However, the development of pasteurized forms and synthetic mediums offers new avenues for its use in clinical settings, as recognized by regulatory bodies like the European Food Safety Authority. This narrative review serves as a crucial resource for understanding the broad implications of A. muciniphila across different health conditions and its potential integration into therapeutic strategies.
摘要：
这篇全面的综述描述了Akkermansiamuciniphila在各种健康领域中的广泛作用，从代谢和炎性疾病到神经退行性疾病。A.粘液虫，以其居住在肠道粘液层中的能力而闻名，在维持肠道完整性和与宿主代谢过程的相互作用中起着关键作用。它的影响延伸到调节免疫反应，并可能缓解几种非传染性疾病的症状，包括肥胖,糖尿病,炎症性肠病，和癌症。最近的研究强调了它与肠-脑轴相互作用的能力，提示可能对神经精神疾病产生影响。尽管在动物和初步的人类研究中强调了粘虫A的有希望的治疗潜力，由于稳定性和栽培问题，其实际应用仍然面临挑战。然而,巴氏杀菌形式和合成培养基的发展为其在临床环境中的使用提供了新的途径，得到欧洲食品安全局等监管机构的认可。这篇叙述性综述是理解A.muciniphila在不同健康状况中的广泛影响及其潜在整合到治疗策略中的重要资源。
