PDF(Pubmed)
Abstract：
Liver cancer ranks third globally among causes of cancer-related deaths, posing a significant public health challenge. However, current treatments are inadequate, prompting a growing demand for novel, safe, and effective therapies. Natural products (NPs) have emerged as promising candidates in drug development due to their diverse biological activities, low toxicity, and minimal side effects. This paper begins by reviewing existing treatment methods and drugs for liver cancer. It then summarizes the therapeutic effects of NPs sourced from various origins on liver cancer. Finally, we analyze the potential mechanisms of NPs in treating liver cancer, including inhibition of angiogenesis, migration, and invasion; regulation of the cell cycle; induction of apoptosis, autophagy, pyroptosis, and ferroptosis; influence on tumor metabolism; immune regulation; regulation of intestinal function; and regulation of key signaling pathways. This systematic review aims to provide a comprehensive overview of NPs research in liver cancer treatment, offering a foundation for further development and application in pharmaceuticals and functional foods.
摘要：
肝癌在全球癌症相关死亡原因中排名第三，构成了重大的公共卫生挑战。然而,目前的治疗方法不足，促使人们对小说的需求不断增长，安全,和有效的治疗方法。天然产物（NPs）由于其多样化的生物活性而成为药物开发中的有希望的候选物。低毒性,和最小的副作用。本文首先对肝癌的现有治疗方法和药物进行综述。然后总结了来自各种来源的NP对肝癌的治疗效果。最后,我们分析了NPs治疗肝癌的潜在机制，包括抑制血管生成，迁移,和侵袭；细胞周期的调节；诱导凋亡，自噬,焦亡,和铁凋亡；对肿瘤代谢的影响；免疫调节；肠道功能的调节；以及关键信号通路的调节。本系统综述旨在全面概述NPs在肝癌治疗中的研究。为药物和功能食品的进一步开发和应用奠定了基础。
