PDF(Pubmed)
Abstract：
A bioactive Pleurotus eryngii aqueous extract powder (SPAE) was obtained by spray drying and its performance in terms of physicochemical properties, in vitro digestion, inflammatory factors, and modulation of the intestinal microbiota was explored. The results indicated that the SPAE exhibited a more uniform particle size distribution than P. eryngii polysaccharide (PEP). Meanwhile, a typical absorption peak observed at 843 cm-1 in the SPAE FTIR spectra indicated the existence of α-glycosidic bonds. SPAE exhibited higher antioxidant abilities and superior resistance to digestion in vitro. In addition, SPAE supplementation to mice significantly reduced the release of factors that promote inflammation, enhanced the secretion of anti-inflammatory factors, and sustained maximum production of short-chain fatty acids (SCFAs). Additionally, it significantly enhanced the relative abundance of SCFAs-producing Akkermansia and reduced the abundance of Ruminococcus and Clostridiides in intestines of mice. These results show the potential of SPAE as a novel material with prebiotic effects for the food and pharmaceutical industries.
摘要：
通过喷雾干燥获得了具有生物活性的杏鲍菇水提物粉末（SPAE），并在理化性质方面表现，体外消化，炎症因子，并探索了肠道微生物群的调节。结果表明，SPAE比杏鲍鱼多糖（PEP）表现出更均匀的粒径分布。同时,在SPAEFTIR光谱中在843cm-1处观察到的典型吸收峰表明存在α-糖苷键。SPAE在体外表现出较高的抗氧化能力和较好的抗消化能力。此外,向小鼠补充SPAE显着减少了促进炎症因子的释放，增强抗炎因子的分泌，以及短链脂肪酸(SCFA)的持续最大产量。此外,它显着提高了产生SCFAs的Akkermansia的相对丰度，并降低了小鼠肠道中Ruminococus和Clostridiides的丰度。这些结果表明了SPAE作为具有益生元效应的新型材料用于食品和制药工业的潜力。
