PDF(Pubmed)
Abstract：
BPA has demonstrated enormous multisystem and multi-organ toxicity shown mainly in animal models. Meanwhile, the effects of its exposure in humans still require years of observation, research, and answers to many questions. Even minimal and short-term exposure contributes to disorders or various types of dysfunction. It is released directly or indirectly into the environment at every stage of the product life cycle, demonstrating its ease of penetration into the body. The ubiquity and general prevalence of BPA influenced the main objective of the study, which was to assess the toxicity and health effects of BPA and its derivatives based on the available literature. In addition, the guidelines of various international institutions or regions of the world in terms of its reduction in individual products were checked. Bisphenol A is the most widely known chemical and perhaps even the most studied by virtually all international or national organizations, but nonetheless, it is still controversial. In general, the level of BPA biomonitoring is still too high and poses a potential threat to public health. It is beginning to be widely argued that future toxicity studies should focus on molecular biology and the assessment of human exposure to BPA, as well as its substitutes. The effects of its exposure still require years of observation, extensive research, and answers to many questions. It is necessary to continue to deepen the knowledge and interest of many organizations, companies, and consumers around the world in order to make rational purchases as well as future choices, not only consumer ones.
摘要：
BPA已显示出巨大的多系统和多器官毒性，主要在动物模型中显示。同时,它暴露在人体中的影响仍然需要多年的观察，研究,并回答了许多问题。即使是最小和短期的暴露也会导致疾病或各种类型的功能障碍。它在产品生命周期的每个阶段都直接或间接地释放到环境中，证明了它易于渗透到体内。BPA的普遍存在和普遍流行影响了研究的主要目标，这是根据现有文献评估BPA及其衍生物的毒性和健康影响。此外,检查了世界上各个国际机构或地区在减少单个产品方面的准则。双酚A是最广为人知的化学物质，甚至可能是几乎所有国际或国家组织研究最多的化学物质。但尽管如此，它仍然有争议。总的来说,BPA生物监测水平仍然过高，对公众健康构成潜在威胁。人们开始广泛认为，未来的毒性研究应集中在分子生物学和评估人类暴露于BPA的评估上，以及它的替代品。它暴露的影响仍然需要多年的观察，广泛的研究，并回答了许多问题。有必要继续加深许多组织的知识和兴趣，公司,和世界各地的消费者为了做出理性的购买以及未来的选择，不仅仅是消费者。
