PDF(Pubmed)
Abstract：
Transdermal drug delivery offers a promising alternative for administering medications like ibuprofen, known for its analgesic and anti-inflammatory properties, with reduced gastrointestinal side effects compared to oral administration. This study explored the potential synergistic effects of combining ibuprofen with lavender essential oil (LEO) in transdermal patches. The composition of LEO was analyzed, revealing predominant compounds such as linalyl acetate and linalool, which are known for their analgesic and anti-inflammatory properties. The physicochemical properties of the patches were investigated, indicating improved cohesion with the addition of LEO. Additionally, thermal stability assessments demonstrated enhanced stability with LEO incorporation with an increase in onset decomposition temperature from 49.0 to 67.9 °C. The antioxidant activity of patches containing LEO was significantly higher with a free radical scavenging ability of 79.13% RSA compared to 60% RSA in patches without LEO. Release and permeation studies showed that patches with LEO exhibited an increased permeation of ibuprofen through the skin with 74.40% of the drug released from LEO-containing patches compared to 36.29% from patches without LEO after 24 h. Moreover, the permeation rate was notably faster with LEO, indicating quicker therapeutic effects. The inclusion of LEO in transdermal patches containing ibuprofen holds promise for enhancing drug delivery efficiency and therapeutic effectiveness, offering a potential strategy for improved pain management with reduced side effects.
摘要：
经皮给药为布洛芬等药物的给药提供了一个有希望的替代方案，以其镇痛和抗炎特性而闻名，与口服相比，胃肠道副作用减少。这项研究探索了布洛芬与薰衣草精油（LEO）在透皮贴剂中的潜在协同作用。分析了LEO的组成，揭示了主要的化合物，如乙酸芳樟醇和芳樟醇，以其镇痛和抗炎特性而闻名。研究了贴片的物理化学性质，表明添加LEO改善了内聚力。此外,热稳定性评估表明，随着起始分解温度从49.0°C增加到67.9°C，LEO掺入的稳定性增强。与不含LEO的贴剂中的60%RSA相比,含LEO的贴剂的抗氧化活性显著更高,具有79.13%RSA的自由基清除能力。释放和渗透研究表明，具有LEO的贴剂显示布洛芬通过皮肤的渗透增加，24小时后，74.40%的药物从含有LEO的贴剂释放，而没有LEO的贴剂为36.29%。LEO的渗透速率明显更快，表明更快的治疗效果。在含有布洛芬的透皮贴剂中加入LEO有望提高药物递送效率和治疗效果，提供改善疼痛管理和减少副作用的潜在策略。
