PDF(Pubmed)
Abstract：
The incidence of thyroid cancer, one of the most common forms of endocrine cancer, is increasing rapidly worldwide in developed and developing countries. Various risk factors can increase susceptibility to thyroid cancer, but particular emphasis is put on the role of DNA repair genes, which have a significant impact on genome stability. Polymorphisms of these genes can increase the risk of developing thyroid cancer by affecting their function. In this article, we present a concise review on the most common polymorphisms of selected DNA repair genes that may influence the risk of thyroid cancer. We point out significant differences in the frequency of these polymorphisms between various populations and their potential relationship with susceptibility to the disease. A more complete understanding of these differences may lead to the development of effective prevention strategies and targeted therapies for thyroid cancer. Simultaneously, there is a need for further research on the role of polymorphisms of previously uninvestigated DNA repair genes in the context of thyroid cancer, which may contribute to filling the knowledge gaps on this subject.
摘要：
甲状腺癌的发病率，最常见的内分泌癌症之一，在世界范围内，发达国家和发展中国家的增长迅速。各种危险因素会增加甲状腺癌的易感性，但特别强调DNA修复基因的作用，对基因组稳定性有重大影响。这些基因的多态性可以通过影响其功能来增加患甲状腺癌的风险。在这篇文章中,我们对可能影响甲状腺癌风险的部分DNA修复基因最常见的多态性进行了简要综述.我们指出了不同人群之间这些多态性频率的显着差异及其与疾病易感性的潜在关系。对这些差异的更全面了解可能会导致制定有效的甲状腺癌预防策略和靶向治疗方法。同时,有必要进一步研究以前未研究的DNA修复基因的多态性在甲状腺癌中的作用，这可能有助于填补这方面的知识空白。
