PDF(Pubmed)
Abstract：
Trained immunity is a concept in immunology in which innate immune cells, such as monocytes and macrophages, exhibit enhanced responsiveness and memory-like characteristics following initial contact with a pathogenic stimulus that may promote a more effective immune defense following subsequent contact with the same pathogen. Helicobacter pylori, a bacterium that colonizes the stomach lining, is etiologically associated with various gastrointestinal diseases, including gastritis, peptic ulcer, gastric adenocarcinoma, MALT lymphoma, and extra gastric disorders. It has been demonstrated that repeated exposure to H. pylori can induce trained immunity in the innate immune cells of the gastric mucosa, which become more responsive and better able to respond to subsequent H. pylori infections. However, interactions between H. pylori and trained immunity are intricate and produce both beneficial and detrimental effects. H. pylori infection is characterized histologically as the presence of both an acute and chronic inflammatory response called acute-on-chronic inflammation, or gastritis. The clinical outcomes of ongoing inflammation include intestinal metaplasia, gastric atrophy, and dysplasia. These same mechanisms may also reduce immunotolerance and trigger autoimmune pathologies in the host. This review focuses on the relationship between trained immunity and H. pylori and underscores the dynamic interplay between the immune system and the pathogen in the context of gastric colonization and inflammation.
摘要：
训练免疫是免疫学中的一个概念，其中先天性免疫细胞，如单核细胞和巨噬细胞，在最初与病原刺激接触后表现出增强的反应性和类似记忆的特征，这可能在随后与相同病原体接触后促进更有效的免疫防御。幽门螺杆菌,一种定植于胃壁的细菌，在病因学上与各种胃肠道疾病相关，包括胃炎,消化性溃疡,胃腺癌,MALT淋巴瘤，和额外的胃部疾病。已经证明，反复暴露于幽门螺杆菌可以在胃粘膜的先天免疫细胞中诱导训练的免疫，变得更敏感，能够更好地应对随后的幽门螺杆菌感染。然而,幽门螺杆菌和受过训练的免疫力之间的相互作用是复杂的，并产生有益和有害的影响。幽门螺杆菌感染的组织学特征是存在急性和慢性炎症反应，称为急性-慢性炎症。或胃炎。持续炎症的临床结果包括肠上皮化生，胃萎缩,和发育不良。这些相同的机制还可以降低免疫耐受性并引发宿主中的自身免疫病理学。这篇综述着重于训练免疫与幽门螺杆菌之间的关系，并强调了在胃定植和炎症的背景下免疫系统与病原体之间的动态相互作用。
