甘氨酸 - 脯氨酸 - 谷氨酸 ( Gly - Pro - Glu ) 共同给药过程中海马淀粉样 β 肽 ( A β ) 含量的降低与炎症和胰岛素样生长因子 ( IGF ) - I 信号转导的变化有关。
关键词: Alzheimer’s disease Gly-Pro-Glu IGF-I signaling cytokines inflammation
Mesh : Animals Amyloid beta-Peptides / metabolism Hippocampus / metabolism drug effects Rats Insulin-Like Growth Factor I / metabolism Signal Transduction / drug effects Female Oligopeptides / pharmacology Inflammation / metabolism drug therapy Peptide Fragments / metabolism Rats, Wistar Alzheimer Disease / metabolism drug therapy p38 Mitogen-Activated Protein Kinases / metabolism Proto-Oncogene Proteins c-akt / metabolism Insulin-Like Peptides
来 源:
DOI:10.3390/ijms25115716
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