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Abstract：
This review addresses the role of tight junction proteins at the blood-brain barrier (BBB). Their expression is described, and their role in physiological and pathological processes at the BBB is discussed. Based on this, new approaches are depicted for paracellular drug delivery and diagnostics in the treatment of cerebral diseases. Recent data provide convincing evidence that, in addition to its impairment in the course of diseases, the BBB could be involved in the aetiology of CNS disorders. Further progress will be expected based on new insights in tight junction protein structure and in their involvement in signalling pathways.
摘要：
本文综述了紧密连接蛋白在血脑屏障（BBB）中的作用。他们的表达被描述，讨论了它们在BBB生理和病理过程中的作用。基于此,描述了用于治疗脑疾病的细胞旁药物递送和诊断的新方法。最近的数据提供了令人信服的证据，除了它在疾病过程中的损害之外，BBB可能与中枢神经系统疾病的病因有关。基于紧密连接蛋白结构及其参与信号通路的新见解，将有望取得进一步进展。
