PDF(Pubmed)
Abstract：
The gut microbiota plays a pivotal role in maintaining the dynamic balance of intestinal epithelial and immune cells, crucial for overall organ homeostasis. Dysfunctions in these intricate relationships can lead to inflammation and contribute to the pathogenesis of various diseases. Recent findings uncovered the existence of a gut-muscle axis, revealing how alterations in the gut microbiota can disrupt regulatory mechanisms in muscular and adipose tissues, triggering immune-mediated inflammation. In the context of Duchenne muscular dystrophy (DMD), alterations in intestinal permeability stand as a potential origin of molecules that could trigger muscle degeneration via various pathways. Metabolites produced by gut bacteria, or fragments of bacteria themselves, may have the ability to migrate from the gut into the bloodstream and ultimately infiltrate distant muscle tissues, exacerbating localized pathologies. These insights highlight alternative pathological pathways in DMD beyond the musculoskeletal system, paving the way for nutraceutical supplementation as a potential adjuvant therapy. Understanding the complex interplay between the gut microbiota, immune system, and muscular health offers new perspectives for therapeutic interventions beyond conventional approaches to efficiently counteract the multifaceted nature of DMD.
摘要：
肠道菌群在维持肠道上皮细胞和免疫细胞的动态平衡中起着关键作用,对整个器官稳态至关重要。这些复杂关系中的功能障碍可导致炎症并有助于各种疾病的发病机理。最近的发现揭示了肠-肌肉轴的存在，揭示肠道微生物群的改变如何破坏肌肉和脂肪组织的调节机制，引发免疫介导的炎症。在Duchenne肌营养不良（DMD）的背景下，肠道通透性的改变是可能通过各种途径引发肌肉变性的分子的潜在来源。肠道细菌产生的代谢物，或者细菌本身的碎片，可能有能力从肠道迁移到血液中，并最终渗入远处的肌肉组织，加剧局部病理。这些见解突出了DMD中肌肉骨骼系统以外的其他病理途径，为营养补充剂作为潜在的辅助治疗铺平了道路。了解肠道微生物群之间复杂的相互作用，免疫系统,和肌肉健康为超越传统方法的治疗干预提供了新的视角，以有效抵消DMD的多面性。
