PDF(Pubmed)
Abstract：
Dogs are considered the main reservoir of several zoonoses endemic to the Mediterranean Basin. In this study, a prevalence of infections and coinfections of canine vector-borne diseases was analyzed in apparently healthy dogs of different canine pure breeds in Sicily (Italy), where these diseases are endemic. The seroprevalence of Leishmania infantum, Ricketsia ricketsii, Anaplasma phagocytophilum, and Erlichia canis was assessed, as single and coinfections. Biochemical and hematological parameters were evaluated, and epidemiological factors, including sex, age, and canine breed, were recovered. The most frequent infection was L. infantum (45.61%), following R. ricketsii (36.84%), both as single, double, or triple coinfections. Coinfections change the biochemical and hematological parameters of the host, and canine breeds are related to the infection frequency and the parameters observed during infections. Changes in the complete blood count (CBC) and biochemical values also differ between canine breeds, with the Cirneco dell\'Etna dogs infected with L. infantum being the animals presenting the most interesting results in our study. High values of RBC, hemoglobin, hematocrit, mean corpuscular hemoglobin (MCH), the albumin/globulin (A/G) ratio, and albumin and low levels of β-2 globulin and γ-globulin were found only in this canine breed, suggesting some resistance to infection in these dogs. Future studies about the immune response of this canine breed could be interesting to determine their possible resistance to zoonotic pathogens, such as L. infantum.
摘要：
狗被认为是地中海盆地特有的几种人畜共患病的主要水库。在这项研究中,在西西里岛（意大利）的不同犬类纯种的明显健康的狗中，分析了犬类媒介传播疾病的感染和合并感染的患病率，这些疾病是地方性的。婴儿利什曼原虫的血清阳性率，立克次体立克次体，吞噬体，并对犬Erlichia进行了评估,作为单一和共同感染。生化和血液学参数进行了评估，和流行病学因素，包括性,年龄,和犬类品种，已恢复。最常见的感染是婴儿乳球菌(45.61%)，在R.Ricketsii（36.84%）之后，都是单身,双,或三重合并感染。共感染改变宿主的生化和血液学参数，犬种与感染频率和感染过程中观察到的参数有关。全血细胞计数（CBC）和生化值的变化在犬种之间也有所不同，Cirnecodell\'Etna狗感染了L.infantum是我们研究中最有趣的结果的动物。红细胞的高值，血红蛋白,血细胞比容,平均红细胞血红蛋白（MCH），白蛋白/球蛋白（A/G）比，仅在该犬种中发现白蛋白和低水平的β-2球蛋白和γ-球蛋白，表明这些狗对感染有一定的抵抗力。关于这种犬科动物的免疫反应的未来研究可能有助于确定它们对人畜共患病原体的可能抗性，比如L.infantum.
