通过单细胞 RNA 测序和验证鉴定 miR - 874 - 3p / ATF3 轴在椎间盘退变中的保护作用。
关键词: ATF3 apoptosis ferroptosis intervertebral disc degeneration miR‐874‐3p single‐cell RNA sequencing
Mesh : Activating Transcription Factor 3 / metabolism genetics Intervertebral Disc Degeneration / genetics metabolism pathology MicroRNAs / genetics metabolism Animals Humans Rats Ferroptosis / genetics Male Nucleus Pulposus / metabolism pathology Single-Cell Analysis / methods Apoptosis / genetics Signal Transduction Female Middle Aged Rats, Sprague-Dawley Sequence Analysis, RNA / methods Extracellular Matrix / metabolism Adult Gene Expression Regulation Disease Models, Animal Computational Biology / methods
来 源:
DOI:10.1111/jcmm.18492
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