PDF(Pubmed)
Abstract：
BACKGROUND: The persistent infection of high-risk Human papillomavirus(HPV) is considered the main cause of cervical intraepithelial neoplasia and cervical cancer. But various cervical lesions caused by HPV infection can be properly prevented by timely vaccination. However, the distribution of HPV genotypes varies geographically.
METHODS: Retrospective analysis of high-risk HPV prevalence of 16,150 women from 2020 to 2022 in xianning of China. HPV genotyping was performed using a PCR-RDB Kit that can detect 18 high-risk HPV genotypes recommended by China\'s National Medical Products Administration. The prevalence of 18 high-risk HPV genotypes and their relationship with cervical lesions as well as vaccine efficacy were analyzed.
RESULTS: A total of 2431 women were confirmed to have different types of high-risk HPV infections. The overall positive rate reached 15.05%(2431/16,150). The most prevalent high-risk HPV genotypes were HPV52, 16, 58, 53, and 51. The prevalence of high-risk HPV reached peak at age ≤ 20(20.95%) and age ≥ 61(20.56%). The most prevalent high-risk HPV genotypes were HPV16, 58, 18, 33 and 52 in cervical cancer cases, HPV16, 52, 58, 33 and 18 in CIN2/3 cases, and HPV52, 58, 16, 53 and 18 in CIN1 cases, respectively.
CONCLUSIONS: HPV16, 58 and 18 are the most dangerous and carcinogenic genotypes in xianning, China. Conducting epidemiological investigations on high-risk HPV has significant clinical value in guiding HPV vaccination work.
METHODS: Retrospective analysis of high-risk HPV prevalence of 16,150 women from 2020 to 2022 in xianning of China. HPV genotyping was performed using a PCR-RDB Kit that can detect 18 high-risk HPV genotypes recommended by China\'s National Medical Products Administration. The prevalence of 18 high-risk HPV genotypes and their relationship with cervical lesions as well as vaccine efficacy were analyzed.
RESULTS: A total of 2431 women were confirmed to have different types of high-risk HPV infections. The overall positive rate reached 15.05%(2431/16,150). The most prevalent high-risk HPV genotypes were HPV52, 16, 58, 53, and 51. The prevalence of high-risk HPV reached peak at age ≤ 20(20.95%) and age ≥ 61(20.56%). The most prevalent high-risk HPV genotypes were HPV16, 58, 18, 33 and 52 in cervical cancer cases, HPV16, 52, 58, 33 and 18 in CIN2/3 cases, and HPV52, 58, 16, 53 and 18 in CIN1 cases, respectively.
CONCLUSIONS: HPV16, 58 and 18 are the most dangerous and carcinogenic genotypes in xianning, China. Conducting epidemiological investigations on high-risk HPV has significant clinical value in guiding HPV vaccination work.
摘要：
背景：高危型人乳头瘤病毒（HPV）的持续感染被认为是宫颈上皮内瘤变和宫颈癌的主要原因。但HPV感染引起的各种宫颈病变可通过及时接种疫苗得到适当预防。然而,HPV基因型的分布在地理上有所不同.
方法：回顾性分析2020-2022年中国咸宁市16,150例女性高危型HPV流行情况。HPV基因分型使用PCR-RDB试剂盒进行，该试剂盒可检测中国国家药品监督管理局推荐的18种高危型HPV基因型。分析18种高危型HPV基因型的患病率及其与宫颈病变的关系以及疫苗的疗效。
结果：共有2431名女性被证实患有不同类型的高危型HPV感染。总阳性率达15.05%(2431/16,150)。最普遍的高危型HPV基因型是HPV52、16、58、53和51。高危型HPV的患病率在≤20岁（20.95%）和≥61岁（20.56%）达到峰值。宫颈癌病例中最常见的高危型HPV基因型是HPV16、58、18、33和52。HPV16、52、58、33和18inCIN2/3例，和HPV52、58、16、53和18在CIN1病例中，分别。
结论：HPV16、58和18是咸宁最危险和致癌的基因型，中国。开展高危型HPV流行病学调查对指导HPV疫苗接种工作具有重要的临床价值。
方法：回顾性分析2020-2022年中国咸宁市16,150例女性高危型HPV流行情况。HPV基因分型使用PCR-RDB试剂盒进行，该试剂盒可检测中国国家药品监督管理局推荐的18种高危型HPV基因型。分析18种高危型HPV基因型的患病率及其与宫颈病变的关系以及疫苗的疗效。
结果：共有2431名女性被证实患有不同类型的高危型HPV感染。总阳性率达15.05%(2431/16,150)。最普遍的高危型HPV基因型是HPV52、16、58、53和51。高危型HPV的患病率在≤20岁（20.95%）和≥61岁（20.56%）达到峰值。宫颈癌病例中最常见的高危型HPV基因型是HPV16、58、18、33和52。HPV16、52、58、33和18inCIN2/3例，和HPV52、58、16、53和18在CIN1病例中，分别。
结论：HPV16、58和18是咸宁最危险和致癌的基因型，中国。开展高危型HPV流行病学调查对指导HPV疫苗接种工作具有重要的临床价值。
