血栓调节蛋白通过抑制氧化和内质网应激在顺铂诱导的肾毒性中的保护作用。
关键词: Acute kidney injury Cisplatin Mice Thrombomodulin Tubular cells
Mesh : Cisplatin / adverse effects Animals Thrombomodulin / metabolism Endoplasmic Reticulum Stress / drug effects Oxidative Stress / drug effects Acute Kidney Injury / chemically induced metabolism drug therapy pathology Mice Reactive Oxygen Species / metabolism Male Apoptosis / drug effects Kidney / drug effects metabolism pathology Antineoplastic Agents / adverse effects toxicity Mice, Inbred C57BL Blood Urea Nitrogen Signal Transduction / drug effects Kidney Tubules, Proximal / drug effects metabolism pathology
来 源:
DOI:10.1038/s41598-024-64619-y
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