Abstract：
Seven previously undescribed compounds, including four diketomorpholine alkaloids (1‒4), one indole diketopiperazine alkaloid (9), one chromone (10), and one benzoic acid derivative (13), and nine known compounds (5-8, 11, 12, and 14-16) were isolated from two different fungal sources. Nine of these metabolites (1-9) were obtained from a seagrass-derived Aspergillus alabamensis SYSU-6778, while the others were obtained from a mixed culture of A. alabamensis SYSU-6778 and a co-isolated fungus A. fumigatiaffinis SYSU-6786. The chemical structures of the compounds were deduced via spectroscopic techniques (including HRESIMS, 1D and 2D NMR), chemical reactions, and ECD calculations. It is worth noting that compound 10 was identified as a defensive secondary metabolite of strain SYSU-6786, produced through the induction of compound 8 under co-culture conditions. Compounds 3 and 4 possessed a naturally rare isotryptophan core. Moreover, compounds 1 and 2 exhibited potent inhibitory activities against fish pathogenic bacterium Edwardsiella ictalurid, with minimum inhibitory concentration values of 10.0 μg/mL for both compounds.
摘要：
七个以前未描述的化合物，包括四种二酮吗啉生物碱（1-4），一种吲哚二酮哌嗪生物碱（9），一种色酮（10），和一种苯甲酸衍生物（13），从两种不同的真菌来源中分离出9种已知化合物（5-8、11、12和14-16）。这些代谢物中的9种（1-9）是从海草衍生的曲霉SYSU-6778中获得的，而其他代谢物则是从A.alabamensisSYSU-6778和共分离的真菌A.fumigatiaffinisSYSU-6786的混合培养物中获得的。通过光谱技术（包括HRESIMS，1D和2DNMR)，化学反应,和ECD计算。值得注意的是,化合物10被鉴定为菌株SYSU-6786的防御性次级代谢物,其通过在共培养条件下诱导化合物8而产生。化合物3和4具有天然罕见的等色氨酸核心。此外，化合物1和2对鱼类病原菌Edwardsiellaictalurid表现出有效的抑制活性，两种化合物的最小抑制浓度值为10.0μg/mL。
