短期冷暴露诱导棕色脂肪持续的表观基因组记忆。
关键词: C/EBPβ ERRα HDAC3 PGC-1α UCP1 brown adipose tissue cold memory mitochondria oxidative phosphorylation thermogenesis
Mesh : Animals Adipose Tissue, Brown / metabolism Cold Temperature Histone Deacetylases / metabolism Mice Mice, Knockout Humans Thermogenesis / genetics Mice, Inbred C57BL CCAAT-Enhancer-Binding Protein-beta / metabolism Uncoupling Protein 1 / metabolism genetics Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / metabolism genetics Male Epigenomics Epigenesis, Genetic
来 源:
DOI:10.1016/j.cmet.2024.05.011
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