双靶点 DYRK2 和 HDAC8 抑制剂治疗肝细胞癌的发现。
关键词: DYRK2 Dual-target inhibitor HDAC8 Hepatocellular carcinoma Structure-based virtual screening
Mesh : Humans Carcinoma, Hepatocellular / drug therapy pathology Liver Neoplasms / drug therapy pathology Dyrk Kinases Animals Protein Serine-Threonine Kinases / antagonists & inhibitors metabolism Protein-Tyrosine Kinases / antagonists & inhibitors metabolism Mice, Nude Histone Deacetylases / metabolism Cell Line, Tumor Xenograft Model Antitumor Assays Repressor Proteins / antagonists & inhibitors metabolism Histone Deacetylase Inhibitors / pharmacology chemistry therapeutic use Cell Proliferation / drug effects Mice, Inbred BALB C Molecular Docking Simulation Mice Antineoplastic Agents / pharmacology Protein Kinase Inhibitors / pharmacology chemistry Drug Discovery Molecular Dynamics Simulation
来 源: DOI:10.1016/j.biopha.2024.116839