关键词: Coinfections Epstein-Barr virus Multiplex PCR toxoplasma uveitis

来  源:   DOI:10.1080/09273948.2024.2367656

Abstract:
UNASSIGNED: To report a case of coinfection of Toxoplasma gondii (Tg) and Epstein Barr Virus (EBV) in a diabetic patient with rheumatoid arthritis and immunosuppressive biological therapy.
UNASSIGNED: A 70-year-old female with a history of rheumatoid arthritis on therapy with corticosteroids, methotrexate, and abatacept presented bilateral granulomatous panuveitis associated with retinal necrosis and macular involvement. A diagnostic vitrectomy detected Tg and EBV. Treatment with clindamycin, trimethoprim-sulfamethoxazole, and acyclovir was established, achieving improvement.
UNASSIGNED: Patients undergoing immunosuppressive therapy are at risk of developing opportunistic infections, often presenting with severe and atypical clinical manifestations. In such cases, multiplex polymerase chain reaction is an invaluable diagnostic tool that helps identify the specific pathogens involved. This enables healthcare professionals to make informed treatment decisions and provide targeted therapy for each identified pathogen.
摘要:
报告1例合并弓形虫(Tg)和爱泼斯坦巴尔病毒(EBV)感染的类风湿关节炎和免疫抑制生物治疗的糖尿病患者。
一名70岁女性,有类风湿性关节炎病史,正在接受皮质类固醇治疗,甲氨蝶呤,和abatacept表现为双侧肉芽肿性葡萄膜炎,伴有视网膜坏死和黄斑受累。诊断性玻璃体切除术检测到Tg和EBV。用克林霉素治疗,甲氧苄啶-磺胺甲恶唑,阿昔洛韦成立了,实现改进。
接受免疫抑制治疗的患者存在机会性感染的风险,常表现为严重和不典型的临床表现。在这种情况下,多重聚合酶链式反应是一种非常有价值的诊断工具,可以帮助识别所涉及的特定病原体。这使医疗保健专业人员能够做出明智的治疗决定,并为每种已识别的病原体提供靶向治疗。
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