Abstract：
UNASSIGNED: Human papillomavirus (HPV) causes several cancers such as cervical cancer and some head and neck (oral cavity, pharynx, and larynx), vulval, vaginal, anal, and penile cancers. As HPV vaccination is available, there is potential to prevent these cancers attributed to HPV and consequently the burden associated with them. The aim of this analysis was to estimate the number of HPV-related cancer deaths and the productivity costs due to years of life lost (YLL) in the United Kingdom (UK).
UNASSIGNED: A model was developed utilizing UK 2019 mortality data sourced from country-specific databases for England, Scotland, Wales, and Northern Ireland for the following HPV-related cancers: head and neck (ICD-10 C00-14 and C32), cervix uteri (C53), vaginal (C51), vulval (C52), anal (C21), and penile (C60). The proportion of deaths and years of life lost (YLL) due to HPV were estimated using HPV attributable fractions for each anatomic location from the published literature. Labor force participation, retirement ages, and mean annual earnings, discounted at 3.5% annually, were applied to YLL to calculate the present value of future lost productivity (PVFLP).
UNASSIGNED: A total of 1817 deaths due to HPV-related cancers were reported in the UK in 2019 resulting in 31,804 YLL. Restricting to only YLL that occurred prior to retirement age yielded a total YPLL of 11,765 and a total PVFLP of £187,764,978.
UNASSIGNED: There is a high disease burden in the UK for HPV-related cancers, with a large economic impact on the wider economy due to productivity losses. Implementing and reinforcing public health measures to maintain high HPV vaccination coverage in both males and females may further facilitate reduction of this burden.
UNASSIGNED: A model was developed utilizing UK 2019 mortality data sourced from country-specific databases for England, Scotland, Wales, and Northern Ireland for the following HPV-related cancers: head and neck (ICD-10 C00-14 and C32), cervix uteri (C53), vaginal (C51), vulval (C52), anal (C21), and penile (C60). The proportion of deaths and years of life lost (YLL) due to HPV were estimated using HPV attributable fractions for each anatomic location from the published literature. Labor force participation, retirement ages, and mean annual earnings, discounted at 3.5% annually, were applied to YLL to calculate the present value of future lost productivity (PVFLP).
UNASSIGNED: A total of 1817 deaths due to HPV-related cancers were reported in the UK in 2019 resulting in 31,804 YLL. Restricting to only YLL that occurred prior to retirement age yielded a total YPLL of 11,765 and a total PVFLP of £187,764,978.
UNASSIGNED: There is a high disease burden in the UK for HPV-related cancers, with a large economic impact on the wider economy due to productivity losses. Implementing and reinforcing public health measures to maintain high HPV vaccination coverage in both males and females may further facilitate reduction of this burden.
摘要：
■人乳头瘤病毒（HPV）会导致多种癌症，例如宫颈癌和某些头颈部（口腔，咽部,和喉)，外阴，阴道,肛门,还有阴茎癌.由于HPV疫苗是可用的，有可能预防这些归因于HPV的癌症，因此与它们相关的负担。该分析的目的是估计在英国(UK)由于多年的生命损失(YLL)导致的HPV相关癌症死亡的数量和生产力成本。
■利用英国2019年死亡率数据开发了一个模型，该数据来自英格兰的特定国家数据库，苏格兰,威尔士,和北爱尔兰以下HPV相关癌症：头颈部（ICD-10C00-14和C32），宫颈（C53），阴道（C51），外阴（C52），肛门（C21），和阴茎（C60）。使用来自已发表文献的每个解剖位置的HPV归因分数来估计由于HPV导致的死亡比例和寿命损失年数(YLL)。劳动力参与，退休年龄,和平均年收入，每年贴现3.5%，将其应用于YLL，以计算未来损失生产力的现值(PVFLP)。
■2019年，英国报告了1,817人死于HPV相关癌症，导致31,804年。仅限于退休年龄之前发生的年历，产生的年历总计为11,765英镑，PVFLP总计为187,764,978英镑。
■在英国，HPV相关癌症的疾病负担很高，由于生产力损失，对更广泛的经济产生了巨大的经济影响。实施和加强公共卫生措施以保持男性和女性的高HPV疫苗接种率可能进一步促进减轻这种负担。
■利用英国2019年死亡率数据开发了一个模型，该数据来自英格兰的特定国家数据库，苏格兰,威尔士,和北爱尔兰以下HPV相关癌症：头颈部（ICD-10C00-14和C32），宫颈（C53），阴道（C51），外阴（C52），肛门（C21），和阴茎（C60）。使用来自已发表文献的每个解剖位置的HPV归因分数来估计由于HPV导致的死亡比例和寿命损失年数(YLL)。劳动力参与，退休年龄,和平均年收入，每年贴现3.5%，将其应用于YLL，以计算未来损失生产力的现值(PVFLP)。
■2019年，英国报告了1,817人死于HPV相关癌症，导致31,804年。仅限于退休年龄之前发生的年历，产生的年历总计为11,765英镑，PVFLP总计为187,764,978英镑。
■在英国，HPV相关癌症的疾病负担很高，由于生产力损失，对更广泛的经济产生了巨大的经济影响。实施和加强公共卫生措施以保持男性和女性的高HPV疫苗接种率可能进一步促进减轻这种负担。
