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Abstract：
OBJECTIVE: To investigate the relationship between corneal diameter and internal corneal span determined from angle-to-angle distance using ultrasound biomicroscopy (UBM) in an observational cross-sectional patient population comprised of 54 eyes (28 healthy control eyes, ages 0.1 to 11.3 years; 26 eyes with primary congenital glaucoma, ages 0.1 to 3.5 years) from 41 pediatric participants ages 0.1 to 11.3 years (mean age: 3±3 years, median age: 2 years).
METHODS: Forty cornea photographs with reference ruler and 110 UBM images were obtained. Three observers measured horizontal and vertical corneal diameter and angle-to-angle distance in each cornea photo and UBM image using ImageJ and the average values were used. Main outcome measures were Pearson correlation coefficient, linear regression, mean difference between corneal diameter and angle-to-angle distance, and intra-class correlation coefficients among measurements from all three observers for each parameter.
RESULTS: Corneal diameter and angle-to-angle distance had a strong positive correlation horizontally (Pearson r = 0.89, p<0.001) and vertically (r = 0.93, p<0.001). Correlation was consistent regardless of presence of primary congenital glaucoma and participant age. Regression analysis demonstrated a linear relationship between the parameters for horizontal (CD = 0.99*AA+0.28, R2 = 0.81, p<0.001) and vertical (CD = 0.91 *AA+1.32, R2 = 0.85, p<0.001) dimensions. Overall, reliability was good-excellent, ranging from an ICC of 0.76 for vertical corneal diameter to 0.90 for horizontal angle-to-angle distance.
CONCLUSIONS: Based on the strong positive correlation found between corneal diameter and angle-to-angle distance in our study population, UBM image analysis can be used to accurately estimate corneal diameter from angle-to-angle distance in children with healthy eyes and primary congenital glaucoma. UBM may provide a useful intraocular alternative for estimating corneal diameter and monitoring diseases that affect the cornea in infants and children, such as congenital glaucoma.
METHODS: Forty cornea photographs with reference ruler and 110 UBM images were obtained. Three observers measured horizontal and vertical corneal diameter and angle-to-angle distance in each cornea photo and UBM image using ImageJ and the average values were used. Main outcome measures were Pearson correlation coefficient, linear regression, mean difference between corneal diameter and angle-to-angle distance, and intra-class correlation coefficients among measurements from all three observers for each parameter.
RESULTS: Corneal diameter and angle-to-angle distance had a strong positive correlation horizontally (Pearson r = 0.89, p<0.001) and vertically (r = 0.93, p<0.001). Correlation was consistent regardless of presence of primary congenital glaucoma and participant age. Regression analysis demonstrated a linear relationship between the parameters for horizontal (CD = 0.99*AA+0.28, R2 = 0.81, p<0.001) and vertical (CD = 0.91 *AA+1.32, R2 = 0.85, p<0.001) dimensions. Overall, reliability was good-excellent, ranging from an ICC of 0.76 for vertical corneal diameter to 0.90 for horizontal angle-to-angle distance.
CONCLUSIONS: Based on the strong positive correlation found between corneal diameter and angle-to-angle distance in our study population, UBM image analysis can be used to accurately estimate corneal diameter from angle-to-angle distance in children with healthy eyes and primary congenital glaucoma. UBM may provide a useful intraocular alternative for estimating corneal diameter and monitoring diseases that affect the cornea in infants and children, such as congenital glaucoma.
摘要：
目的：在由54只眼（28只健康对照眼，年龄0.1至11.3岁;26眼原发性先天性青光眼,年龄0.1至3.5岁）从41名0.1至11.3岁的儿科参与者（平均年龄：3±3岁，中位年龄：2岁）。
方法：获得了40张带有参考尺的角膜照片和110张UBM图像。三个观察者使用ImageJ测量每个角膜照片和UBM图像中的水平和垂直角膜直径以及角度到角度的距离，并使用平均值。主要结局指标为皮尔逊相关系数，线性回归，角膜直径和角度距离之间的平均差，以及所有三个观察者对每个参数的测量结果之间的类内相关系数。
结果：角膜直径和角度-角度距离水平（Pearsonr=0.89，p<0.001）和垂直（r=0.93，p<0.001）具有很强的正相关性。无论是否存在原发性先天性青光眼和参与者年龄，相关性都是一致的。回归分析显示水平(CD=0.99*AA+0.28,R2=0.81,p<0.001)和垂直(CD=0.91*AA+1.32,R2=0.85,p<0.001)尺寸的参数之间呈线性关系。总的来说,可靠性很好-很好，范围从垂直角膜直径的ICC为0.76到水平角度到角度距离的ICC为0.90。
结论：基于在我们的研究人群中发现的角膜直径和角度到角度距离之间的强正相关，UBM图像分析可用于从角度到角度的距离准确估计健康眼睛和原发性先天性青光眼儿童的角膜直径。UBM可以为估计角膜直径和监测影响婴儿和儿童角膜的疾病提供有用的眼内替代方法。如先天性青光眼。
方法：获得了40张带有参考尺的角膜照片和110张UBM图像。三个观察者使用ImageJ测量每个角膜照片和UBM图像中的水平和垂直角膜直径以及角度到角度的距离，并使用平均值。主要结局指标为皮尔逊相关系数，线性回归，角膜直径和角度距离之间的平均差，以及所有三个观察者对每个参数的测量结果之间的类内相关系数。
结果：角膜直径和角度-角度距离水平（Pearsonr=0.89，p<0.001）和垂直（r=0.93，p<0.001）具有很强的正相关性。无论是否存在原发性先天性青光眼和参与者年龄，相关性都是一致的。回归分析显示水平(CD=0.99*AA+0.28,R2=0.81,p<0.001)和垂直(CD=0.91*AA+1.32,R2=0.85,p<0.001)尺寸的参数之间呈线性关系。总的来说,可靠性很好-很好，范围从垂直角膜直径的ICC为0.76到水平角度到角度距离的ICC为0.90。
结论：基于在我们的研究人群中发现的角膜直径和角度到角度距离之间的强正相关，UBM图像分析可用于从角度到角度的距离准确估计健康眼睛和原发性先天性青光眼儿童的角膜直径。UBM可以为估计角膜直径和监测影响婴儿和儿童角膜的疾病提供有用的眼内替代方法。如先天性青光眼。
