Abstract:
The review presents the results of the blood substitute development based on perfluororganic compounds (PFC). The limitations of PFC due to which their further development was suspended are described. The presented data allows us to imagine a possible way to create optimal drugs based on PFC. Chemically inactive perfluorocomponents should be used - perfluorinated hydrocarbons and tertiary perfluorinated amines. However, in order to emulsify and stabilize the emulsion, other types of effective and chemically indifferent surfactants that do not interact with oxygen and other components of the drug are needed.
摘要:
该综述介绍了基于全氟有机化合物(PFC)的血液替代品开发的结果。描述了PFC的局限性,因此暂停了进一步的开发。所提供的数据使我们能够想象一种基于PFC创建最佳药物的可能方法。应使用化学惰性的全氟组分-全氟烃和叔全氟胺。然而,为了乳化和稳定乳液,需要其他类型的有效和化学无关的表面活性剂,这些表面活性剂不与氧气和药物的其他成分相互作用。