PDF(Pubmed)
Abstract：
UNASSIGNED: Structured aerobic or resistance training alone seems to be a beneficial tool for improving glucose homeostasis, chronic systemic inflammation, resting cardiovascular function, and mental health in people with obesity and type 2 diabetes mellitus (T2DM). The aim of the present study was to synthesize the available data on the effectiveness of combined aerobic and resistance training (CART) on glycemic control, blood pressure, inflammation, cardiorespiratory fitness (CRF), and quality of life (QoL) in overweight and obese individuals with T2DM.
UNASSIGNED: A database search was carried out in PubMed, Web of Science, Scopus, Science Direct, Cochrane Library, and Google Scholar from inception up to May 2023. The Cochrane risk of bias tool was used to assess eligible studies, and the GRADE method to evaluate the reliability of evidence. A random-effects model was used, and data were analyzed using standardized mean differences and 95% confidence intervals. The study protocol was registered in the International Prospective Register of Systematic Reviews (ID: CRD42022355612).
UNASSIGNED: A total of 21,612 studies were retrieved; 20 studies were included, and data were extracted from 1,192 participants (mean age: 57 ± 7 years) who met the eligibility criteria. CART demonstrated significant improvements in body mass index, glycated hemoglobin, systolic and diastolic blood pressure, C-reactive protein, tumor necrosis factor-alpha, interleukin-6, CRF, and QoL compared to ST. These findings highlight the significance of exercise interventions such as CART as essential elements within comprehensive diabetes management strategies, ultimately enhancing overall health outcomes in individuals with T2DM and overweight/obesity.No differences were found in resting heart rate between CART and ST. An uncertain risk of bias and poor quality of evidence were found among the eligible studies.
UNASSIGNED: These outcomes show clear evidence considering the positive role of CART in inducing beneficial changes in various cardiometabolic and mental health-related indicators in patients with T2DM and concurrent overweight/obesity. More studies with robust methodological design are warranted to examine the dose-response relationship, training parameters configuration, and mechanisms behind these positive adaptations.
UNASSIGNED: A database search was carried out in PubMed, Web of Science, Scopus, Science Direct, Cochrane Library, and Google Scholar from inception up to May 2023. The Cochrane risk of bias tool was used to assess eligible studies, and the GRADE method to evaluate the reliability of evidence. A random-effects model was used, and data were analyzed using standardized mean differences and 95% confidence intervals. The study protocol was registered in the International Prospective Register of Systematic Reviews (ID: CRD42022355612).
UNASSIGNED: A total of 21,612 studies were retrieved; 20 studies were included, and data were extracted from 1,192 participants (mean age: 57 ± 7 years) who met the eligibility criteria. CART demonstrated significant improvements in body mass index, glycated hemoglobin, systolic and diastolic blood pressure, C-reactive protein, tumor necrosis factor-alpha, interleukin-6, CRF, and QoL compared to ST. These findings highlight the significance of exercise interventions such as CART as essential elements within comprehensive diabetes management strategies, ultimately enhancing overall health outcomes in individuals with T2DM and overweight/obesity.No differences were found in resting heart rate between CART and ST. An uncertain risk of bias and poor quality of evidence were found among the eligible studies.
UNASSIGNED: These outcomes show clear evidence considering the positive role of CART in inducing beneficial changes in various cardiometabolic and mental health-related indicators in patients with T2DM and concurrent overweight/obesity. More studies with robust methodological design are warranted to examine the dose-response relationship, training parameters configuration, and mechanisms behind these positive adaptations.
摘要：
■单纯的结构化有氧或抗阻训练似乎是改善葡萄糖稳态的有益工具，慢性全身性炎症，静息心血管功能，肥胖和2型糖尿病（T2DM）患者的心理健康。本研究的目的是综合有关有氧和抗阻联合训练（CART）对血糖控制的有效性的可用数据，血压,炎症,心肺健康（CRF），超重和肥胖2型糖尿病患者的生活质量(QoL)。
■在PubMed中进行了数据库搜索，WebofScience,Scopus,科学直接，科克伦图书馆,和谷歌学者从成立到2023年5月。Cochrane偏倚风险工具用于评估符合条件的研究，并采用GRADE法对证据的可靠性进行评价。使用了随机效应模型，数据采用标准化均差和95%置信区间进行分析.研究方案已在国际前瞻性系统评价注册（ID：CRD420223555612）中注册。
■共检索到21,612项研究；包括20项研究，数据来自符合入选标准的1,192名参与者(平均年龄:57±7岁).CART显示出体重指数的显着改善，糖化血红蛋白,收缩压和舒张压,C反应蛋白,肿瘤坏死因子-α,白细胞介素-6，CRF，和QoL与ST相比。这些发现强调了运动干预措施的重要性，如CART作为糖尿病综合管理策略的基本要素。最终提高2型糖尿病和超重/肥胖患者的整体健康结局.CART和ST之间的静息心率没有差异。在符合条件的研究中发现了不确定的偏倚风险和证据质量差。
这些结果显示了明确的证据，考虑到CART在诱导T2DM和并发超重/肥胖患者各种心脏代谢和心理健康相关指标的有益变化中的积极作用。有必要进行更多具有稳健方法学设计的研究来检查剂量反应关系，训练参数配置，以及这些积极适应背后的机制。
■在PubMed中进行了数据库搜索，WebofScience,Scopus,科学直接，科克伦图书馆,和谷歌学者从成立到2023年5月。Cochrane偏倚风险工具用于评估符合条件的研究，并采用GRADE法对证据的可靠性进行评价。使用了随机效应模型，数据采用标准化均差和95%置信区间进行分析.研究方案已在国际前瞻性系统评价注册（ID：CRD420223555612）中注册。
■共检索到21,612项研究；包括20项研究，数据来自符合入选标准的1,192名参与者(平均年龄:57±7岁).CART显示出体重指数的显着改善，糖化血红蛋白,收缩压和舒张压,C反应蛋白,肿瘤坏死因子-α,白细胞介素-6，CRF，和QoL与ST相比。这些发现强调了运动干预措施的重要性，如CART作为糖尿病综合管理策略的基本要素。最终提高2型糖尿病和超重/肥胖患者的整体健康结局.CART和ST之间的静息心率没有差异。在符合条件的研究中发现了不确定的偏倚风险和证据质量差。
这些结果显示了明确的证据，考虑到CART在诱导T2DM和并发超重/肥胖患者各种心脏代谢和心理健康相关指标的有益变化中的积极作用。有必要进行更多具有稳健方法学设计的研究来检查剂量反应关系，训练参数配置，以及这些积极适应背后的机制。
