UNASSIGNED: With the use of a two-sample Mendelian randomization (MR) technique, we assessed the causal relationship between GERD and AF. The association of genetic variants with GERD was examined using data from a recent genome-wide association study (GWAS) that included 602,604 people. Data on the association between genetic variations and AF was obtained from a second GWAS with 1,030,836 participants. The effect sizes were examined based on the inverse-variance weighted method. Additional statistical techniques, including MR-Egger, simple mode, weighted mode, MR Pleiotropy Residual Sum, outlier, and weighted median were used in the sensitivity analysis.
UNASSIGNED: MR analyses in inverse-variance weighted models, using 76 single nucleotide polymorphisms (SNPs) as markers, revealed a relationship between genetically predicted GERD and a greater AF incidence [odds ratio (OR): 1.165, 95% CI 1.102-1.231; P = 7.637 × 10-8]. According to MR-Egger, there was no evidence of gene pleiotropy that could be found (intercept = 0.003, P = 0.581). The findings of the sensitivity study, which used several MR methods, were found to be reliable.
UNASSIGNED: The MR analysis revealed a correlation between GERD and increased AF incidence, supporting the idea that treating patients with GERD as early as possible might reduce their chance of developing AF.
■使用双样本孟德尔随机化(MR)技术,我们评估了GERD与AF之间的因果关系.使用最近的全基因组关联研究(GWAS)的数据检查了遗传变异与GERD的关联,该研究包括602,604人。关于遗传变异和AF之间的关联的数据是从第二个GWAS获得的,有1,030,836名参与者。基于逆方差加权方法检查了效应大小。其他统计技术,包括MR-Egger,简单模式,加权模式,MR辉变剩余和,离群值,和加权中位数用于敏感性分析。
■逆方差加权模型中的MR分析,使用76个单核苷酸多态性(SNP)作为标记,揭示了遗传预测的GERD与更高的AF发生率之间的关系[比值比(OR):1.165,95%CI1.102-1.231;P=7.637×10-8]。根据MR-Egger的说法,没有发现基因多效性的证据(截距=0.003,P=0.581).敏感性研究的结果,使用了几种MR方法,被发现是可靠的。
■MR分析显示GERD与房颤发生率增加之间存在相关性,支持尽早治疗GERD患者可能会减少他们发生房颤的机会。