PDF(Pubmed)
Abstract：
Allergic respiratory diseases can increase serum carcinoembryonic antigen levels. We report three cases experiencing allergic symptoms that proved refractory to inhaled corticosteroids but exhibited a positive response to long-term treatment with oral corticosteroids. This response was characterized by a synchronous alteration in serum eosinophil counts and carcinoembryonic antigen levels. Immunofluorescence assays indicated localized carcinoembryonic antigen production within eosinophils. In addition, we conducted a systematic review of patients exhibiting similar characteristics on PubMed. After comprehensively reviewing this unique pathophysiological condition, we herein introduced a novel term \"Allergic hyper-carcinoembryonic antigen syndrome,\" defined by the following criteria: (1) recurrent asthmatic attacks; (2) eosinophilia or pulmonary eosinophilic infiltrations accompanied by elevated serum carcinoembryonic antigen levels; (3) pulmonary lesions determined by imaging or biopsy; (4) exclusion of malignancy and infections; and (5) responsive to systemic corticosteroids. Allergic hyper-carcinoembryonic antigen syndrome suggests systemic corticosteroids should be introduced early when managing allergic patients with both eosinophilia and elevated serum carcinoembryonic antigen levels.
摘要：
过敏性呼吸系统疾病可增加血清癌胚抗原水平。我们报告了三例出现过敏症状的病例，这些症状被证明对吸入糖皮质激素难以治疗，但对口服糖皮质激素的长期治疗表现出阳性反应。这种反应的特征是血清嗜酸性粒细胞计数和癌胚抗原水平的同步变化。免疫荧光测定表明嗜酸性粒细胞内局部产生癌胚抗原。此外,我们对在PubMed上表现出相似特征的患者进行了系统评价.在全面回顾了这种独特的病理生理状况后，我们在此引入了一个新术语“过敏性高癌胚抗原综合征，“由以下标准定义：（1）反复哮喘发作；（2）嗜酸性粒细胞增多或肺嗜酸性粒细胞浸润伴有血清癌胚抗原水平升高；（3）通过影像学或活检确定的肺部病变；（4）排除恶性肿瘤和感染；（5）对全身性皮质类固醇有反应。过敏性高癌胚抗原综合征表明，在治疗嗜酸粒细胞增多和血清癌胚抗原水平升高的过敏性患者时，应尽早引入全身性皮质类固醇。
