{Reference Type}: Case Reports
{Title}: Allergic hyper-carcinoembryonic antigen syndrome: A syndrome summarized by case series.
{Author}: Li Z;Hong L;Li Y;Lin X;Chen M;Bu S;Xu S;Zeng Q;Huang Y;Bian L;Zheng J;Gao B;Liu G;He W;Song X;Ye F;Huang L;Jiang S;Shi J;Tang T;
{Journal}: SAGE Open Med Case Rep
{Volume}: 12
{Issue}: 0
{Year}: 2024
暂无{DOI}: 10.1177/2050313X241261152
{Abstract}: Allergic respiratory diseases can increase serum carcinoembryonic antigen levels. We report three cases experiencing allergic symptoms that proved refractory to inhaled corticosteroids but exhibited a positive response to long-term treatment with oral corticosteroids. This response was characterized by a synchronous alteration in serum eosinophil counts and carcinoembryonic antigen levels. Immunofluorescence assays indicated localized carcinoembryonic antigen production within eosinophils. In addition, we conducted a systematic review of patients exhibiting similar characteristics on PubMed. After comprehensively reviewing this unique pathophysiological condition, we herein introduced a novel term "Allergic hyper-carcinoembryonic antigen syndrome," defined by the following criteria: (1) recurrent asthmatic attacks; (2) eosinophilia or pulmonary eosinophilic infiltrations accompanied by elevated serum carcinoembryonic antigen levels; (3) pulmonary lesions determined by imaging or biopsy; (4) exclusion of malignancy and infections; and (5) responsive to systemic corticosteroids. Allergic hyper-carcinoembryonic antigen syndrome suggests systemic corticosteroids should be introduced early when managing allergic patients with both eosinophilia and elevated serum carcinoembryonic antigen levels.