PDF(Pubmed)
Abstract：
BACKGROUND: Rapamycin has been extensively utilized for coating coronary artery stents to reduce the occurrence of restenosis, yet there has been limited research on the potential harms of rapamycin-eluting stents. Herein, We report a case of eosinophilia and interstitial pneumonia caused by a cobalt-based alloy stent eluted with rapamycin.
METHODS: The patient was admitted due to fever, cough, and expectoration symptoms. Previously, the patient had undergone a procedure of percutaneous coronary stent implantation in our hospital\'s cardiology department, which led to a gradual rise in blood eosinophil count. This time, the eosinophil count was higher than the previous admission. A chest CT scan revealed multiple flocculent density increases in both lungs and bronchiectasis. The rapamycin-eluting stents may have caused eosinophilia and interstitial pneumonia, which improved after administering corticosteroids. A systematic review of relevant literature was conducted to summarize the characteristics of interstitial pneumonia caused by drug-eluting stents.
CONCLUSIONS: Paclitaxel, everolimus, zotarolimus, and rapamycin are the types of drugs that can lead to drug-eluting stents, and because of the rarity of their onset, clinical doctors must be precise and prompt in diagnosing suspected cases to avoid misdiagnosis and delayed treatment.
METHODS: The patient was admitted due to fever, cough, and expectoration symptoms. Previously, the patient had undergone a procedure of percutaneous coronary stent implantation in our hospital\'s cardiology department, which led to a gradual rise in blood eosinophil count. This time, the eosinophil count was higher than the previous admission. A chest CT scan revealed multiple flocculent density increases in both lungs and bronchiectasis. The rapamycin-eluting stents may have caused eosinophilia and interstitial pneumonia, which improved after administering corticosteroids. A systematic review of relevant literature was conducted to summarize the characteristics of interstitial pneumonia caused by drug-eluting stents.
CONCLUSIONS: Paclitaxel, everolimus, zotarolimus, and rapamycin are the types of drugs that can lead to drug-eluting stents, and because of the rarity of their onset, clinical doctors must be precise and prompt in diagnosing suspected cases to avoid misdiagnosis and delayed treatment.
摘要：
背景：雷帕霉素已被广泛用于涂覆冠状动脉支架，以减少再狭窄的发生，然而，关于雷帕霉素洗脱支架潜在危害的研究有限。在这里，我们报告了一例由雷帕霉素洗脱的钴基合金支架引起的嗜酸性粒细胞增多和间质性肺炎。
方法：患者因发热入院，咳嗽,和咳痰症状。以前,患者在我院心内科接受了经皮冠状动脉支架植入术,导致血液嗜酸性粒细胞计数逐渐上升。这一次,嗜酸性粒细胞计数高于之前的入院.胸部CT扫描显示肺部和支气管扩张中的多个絮凝密度增加。雷帕霉素洗脱支架可能引起嗜酸性粒细胞增多和间质性肺炎,服用皮质类固醇后有所改善。系统复习相关文献,总结药物洗脱支架所致间质性肺炎的特点。
结论：紫杉醇，依维莫司,佐他莫司,雷帕霉素是可以导致药物洗脱支架的药物类型，因为它们很少发作，临床医生在诊断疑似病例时必须准确及时，以避免误诊和延误治疗。
方法：患者因发热入院，咳嗽,和咳痰症状。以前,患者在我院心内科接受了经皮冠状动脉支架植入术,导致血液嗜酸性粒细胞计数逐渐上升。这一次,嗜酸性粒细胞计数高于之前的入院.胸部CT扫描显示肺部和支气管扩张中的多个絮凝密度增加。雷帕霉素洗脱支架可能引起嗜酸性粒细胞增多和间质性肺炎,服用皮质类固醇后有所改善。系统复习相关文献,总结药物洗脱支架所致间质性肺炎的特点。
结论：紫杉醇，依维莫司,佐他莫司,雷帕霉素是可以导致药物洗脱支架的药物类型，因为它们很少发作，临床医生在诊断疑似病例时必须准确及时，以避免误诊和延误治疗。
