%0 Systematic Review
%T Coronary stent implantation links to the occurrence of eosinophilia and interstitial pneumonia: a case report and systematic review.
%A Zhang F
%A Wang W
%A Zhu Y
%A Mao Y
%A Wang T
%A Gao P
%J BMC Pulm Med
%V 24
%N 1
%D 2024 Jun 17
%M 38886703
%F 3.32
%R 10.1186/s12890-024-03101-x
%X <B>BACKGROUND: </B>Rapamycin has been extensively utilized for coating coronary artery stents to reduce the occurrence of restenosis, yet there has been limited research on the potential harms of rapamycin-eluting stents. Herein, We report a case of eosinophilia and interstitial pneumonia caused by a cobalt-based alloy stent eluted with rapamycin.<BR><B>METHODS: </B>The patient was admitted due to fever, cough, and expectoration symptoms. Previously, the patient had undergone a procedure of percutaneous coronary stent implantation in our hospital's cardiology department, which led to a gradual rise in blood eosinophil count. This time, the eosinophil count was higher than the previous admission. A chest CT scan revealed multiple flocculent density increases in both lungs and bronchiectasis. The rapamycin-eluting stents may have caused eosinophilia and interstitial pneumonia, which improved after administering corticosteroids. A systematic review of relevant literature was conducted to summarize the characteristics of interstitial pneumonia caused by drug-eluting stents.<BR><B>CONCLUSIONS: </B>Paclitaxel, everolimus, zotarolimus, and rapamycin are the types of drugs that can lead to drug-eluting stents, and because of the rarity of their onset, clinical doctors must be precise and prompt in diagnosing suspected cases to avoid misdiagnosis and delayed treatment.