Abstract：
OBJECTIVE: Longitudinal assessment of the role of specific proteins on radiotherapy caries (RC) onset in head and neck cancer patients(HNC) up to one-year post-IMRT using a 5000ppm fluoride paste daily.
METHODS: Dental status/salivary protein data were obtained from 40 HNC patients pre-IMRT, six months (T1) and 12 months (T2) post-IMRT (ethical approval/consent). DMFT/salivary parameters were quantified, including flow rate, mucin 5B/7, Immunoglobulin A (IgA), cystatin S and α-amylase.
RESULTS: 45% patients had at least one carious lesion at T2, a significant reduction in the number of remaining teeth (65% <21), salivary flow rate (< 50%) and, protein secretion (< 0.05) post-IMRT. T1 IgA concentration/secretion rate was associated with RC (p < 0.05). Finally, IgA and total protein concentration obtained at T1 could provide a predictive pattern (AUC 82.3%) for the patients more predisposed to developing RC at T2.
CONCLUSIONS: This study demonstrated the significant association of RC with salivary proteins in HNC patients treated with IMRT, revealing the potential role of salivary proteins in the early diagnosis of RC.
CONCLUSIONS: This research contributes to revealing salivary proteins association with RC, and its role in early diagnosis. Therefore, this could be the first step towards personalized medicine approaches to improve this group quality-of-life.
METHODS: Dental status/salivary protein data were obtained from 40 HNC patients pre-IMRT, six months (T1) and 12 months (T2) post-IMRT (ethical approval/consent). DMFT/salivary parameters were quantified, including flow rate, mucin 5B/7, Immunoglobulin A (IgA), cystatin S and α-amylase.
RESULTS: 45% patients had at least one carious lesion at T2, a significant reduction in the number of remaining teeth (65% <21), salivary flow rate (< 50%) and, protein secretion (< 0.05) post-IMRT. T1 IgA concentration/secretion rate was associated with RC (p < 0.05). Finally, IgA and total protein concentration obtained at T1 could provide a predictive pattern (AUC 82.3%) for the patients more predisposed to developing RC at T2.
CONCLUSIONS: This study demonstrated the significant association of RC with salivary proteins in HNC patients treated with IMRT, revealing the potential role of salivary proteins in the early diagnosis of RC.
CONCLUSIONS: This research contributes to revealing salivary proteins association with RC, and its role in early diagnosis. Therefore, this could be the first step towards personalized medicine approaches to improve this group quality-of-life.
摘要：
目的：每天使用5000ppm氟化物糊剂对头颈部癌症（HNC）患者在IMRT后一年内放疗龋齿（RC）发作的特定蛋白的作用进行纵向评估。
方法：从IMRT前的40例HNC患者获得牙齿状态/唾液蛋白数据，6个月（T1）和12个月（T2）后IMRT（伦理批准/同意）。DMFT/唾液参数进行了量化，包括流量，黏蛋白5B/7，免疫球蛋白A（IgA），胱抑素S和α-淀粉酶。
结果：45％的患者在T2时至少有一个龋齿病变，剩余牙齿数量显着减少（65％<21），唾液流速（<50%）和，IMRT后蛋白质分泌(<0.05)。T1IgA浓度/分泌率与RC相关(p<0.05)。最后,在T1获得的IgA和总蛋白浓度可以为更倾向于在T2发展RC的患者提供预测模式(AUC82.3%)。
结论：这项研究表明，在接受IMRT治疗的HNC患者中，RC与唾液蛋白显著相关，揭示唾液蛋白在RC早期诊断中的潜在作用。
结论：这项研究有助于揭示唾液蛋白与RC，及其在早期诊断中的作用。因此,这可能是改善这一群体生活质量的个性化医疗方法的第一步.
方法：从IMRT前的40例HNC患者获得牙齿状态/唾液蛋白数据，6个月（T1）和12个月（T2）后IMRT（伦理批准/同意）。DMFT/唾液参数进行了量化，包括流量，黏蛋白5B/7，免疫球蛋白A（IgA），胱抑素S和α-淀粉酶。
结果：45％的患者在T2时至少有一个龋齿病变，剩余牙齿数量显着减少（65％<21），唾液流速（<50%）和，IMRT后蛋白质分泌(<0.05)。T1IgA浓度/分泌率与RC相关(p<0.05)。最后,在T1获得的IgA和总蛋白浓度可以为更倾向于在T2发展RC的患者提供预测模式(AUC82.3%)。
结论：这项研究表明，在接受IMRT治疗的HNC患者中，RC与唾液蛋白显著相关，揭示唾液蛋白在RC早期诊断中的潜在作用。
结论：这项研究有助于揭示唾液蛋白与RC，及其在早期诊断中的作用。因此,这可能是改善这一群体生活质量的个性化医疗方法的第一步.
