PDF(Pubmed)
Abstract：
Understanding the transfer of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in farm animals is essential for ensuring food safety, but such information for suckler ewes (Ovis aries) has been lacking. This work quantifies the accumulation, tissue distribution, and depuration kinetics of PCDD/Fs in these animals. Six suckler ewes (EXP group) were exposed to PCDD/Fs through contaminated hay (2.3-12.7 ng toxic-equivalent kg-1 dry matter) and then allowed to depurate by switching to noncontaminated hay from 29 days of lactation. Four control ewes were fed continuously with noncontaminated hay. At different time points covering depuration, weaning and slaughter, PCDD/F analysis of milk (three time points), blood and sternal adipose tissue (five time points), Longissimus thoracis muscle, liver, and empty body homogenate at slaughter (188 days of depuration) was performed. A relevant PCDD/F bioaccumulation was observed from oral intake in milk and adipose tissue (biotransfer factors of 1.24 and 1.06 day kg-1 lipids for the sum toxic-equivalent, respectively) in the EXP ewes, especially for penta- and hexa-chlorinated congeners. The EXP ewes\' adipose tissue started at 10-fold the EU maximum level (ML) and showed depuration below the ML after 130 days. Specific PCDD/F accumulation in the ewe liver was observed, especially for dibenzofurans. These toxicokinetic data can inform recommendations to ensure the chemical safety of sheep food products.
摘要：
了解多氯二苯并二恶英和二苯并呋喃（PCDD/Fs）在农场动物中的转移对于确保食品安全至关重要，但是对于乳牛母羊(Ovisaries)来说，这种信息一直缺乏。这项工作量化了积累，组织分布,和PCDD/Fs在这些动物中的净化动力学。六只母羊（EXP组）通过受污染的干草（2.3-12.7ng毒性当量kg-1干物质）暴露于PCDD/Fs，然后从哺乳期29天开始转换为无污染的干草，使其净化。四只对照母羊连续饲喂无污染的干草。在不同的时间点，包括净化，断奶和屠宰，牛奶的PCDD/F分析（三个时间点），血液和胸骨脂肪组织（五个时间点），胸椎肌,肝脏,并在屠宰时进行空体匀浆（净化188天）。从牛奶和脂肪组织中的口服摄入中观察到相关的PCDD/F生物累积(总毒性当量为1.24天和1.06天kg-1脂质的生物转化因子,分别)在EXP母羊中，尤其是五氯化和六氯化同源物。EXP母羊脂肪组织从EU最大水平（ML）的10倍开始，并在130天后显示低于ML的净化。观察到母羊肝脏中特定的PCDD/F积累，尤其是二苯并呋喃。这些毒物动力学数据可以提供建议，以确保绵羊食品的化学安全性。
