Abstract：
Evidence suggests a role for low-grade inflammation and oxidative stress in the pathophysiology of bipolar disorder. We conducted a systematic review and meta-analysis of peripheral markers of inflammation and oxidative stress in children and adolescents under 20 years of age with bipolar disorder. We searched PubMed, Embase and psycINFO and performed random effects meta-analysis calculating standardized mean differences (SMD) of marker levels between patients with bipolar disorder and healthy control individuals. Ten studies comprising a total of 418 patients with bipolar disorder and 3017 healthy control individuals were included. The levels of C-Reactive Protein were higher in patients with bipolar disorder compared with healthy individuals (SMD 0.53; 95 %CI: 0.33-0.74; I2 = 0 %). For other biomarkers there were no statistically significant differences between groups. Findings were limited by a low number of studies and participants and methodological issues in the included studies. More and larger studies using rigorous methodology are needed to establish the role of inflammation and oxidative stress in children and adolescents with bipolar disorder.
摘要：
证据表明，低度炎症和氧化应激在双相情感障碍的病理生理学中的作用。我们对20岁以下双相情感障碍儿童和青少年的炎症和氧化应激的外周标志物进行了系统评价和荟萃分析。我们搜索了PubMed,Embase和psycINFO并进行随机效应荟萃分析，计算双相情感障碍患者和健康对照个体之间标志物水平的标准化平均差异（SMD）。纳入了10项研究，共418名双相情感障碍患者和3017名健康对照个体。与健康个体相比，双相情感障碍患者的C反应蛋白水平更高（SMD0.53;95CI：0.33-0.74;I2=0％）。对于其他生物标志物,组间没有统计学显著差异。研究结果受到研究和参与者数量少以及纳入研究的方法学问题的限制。需要使用严格的方法进行更多和更大的研究来确定炎症和氧化应激在患有双相情感障碍的儿童和青少年中的作用。
